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Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation.
Serra A, Fratello M, Federico A, Ojha R, Provenzani R, Tasnadi E, Cattelani L, Del Giudice G, Kinaret PAS, Saarimäki LA, Pavel A, Kuivanen S, Cerullo V, Vapalahti O, Horvath P, Lieto AD, Yli-Kauhaluoma J, Balistreri G, Greco D. Serra A, et al. Among authors: balistreri g. Brief Bioinform. 2022 Jan 17;23(1):bbab507. doi: 10.1093/bib/bbab507. Brief Bioinform. 2022. PMID: 34962256 Free PMC article.
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Cantuti-Castelvetri L, et al. Among authors: balistreri g. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20. Science. 2020. PMID: 33082293 Free PMC article.
SARS-CoV-2 requires acidic pH to infect cells.
Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Correia RBDC, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T. Kreutzberger AJB, et al. Among authors: balistreri g. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2209514119. doi: 10.1073/pnas.2209514119. Epub 2022 Sep 1. Proc Natl Acad Sci U S A. 2022. PMID: 36048924 Free PMC article.
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT. Yang K, et al. Among authors: balistreri g. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210990119. doi: 10.1073/pnas.2210990119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122200 Free PMC article.
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.
Kettunen P, Lesnikova A, Räsänen N, Ojha R, Palmunen L, Laakso M, Lehtonen Š, Kuusisto J, Pietiläinen O, Saber SH, Joensuu M, Vapalahti OP, Koistinaho J, Rolova T, Balistreri G. Kettunen P, et al. Among authors: balistreri g. J Virol. 2023 Apr 27;97(4):e0014423. doi: 10.1128/jvi.00144-23. Epub 2023 Apr 11. J Virol. 2023. PMID: 37039676 Free PMC article.
Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors.
Kant R, Kareinen L, Ojha R, Strandin T, Saber SH, Lesnikova A, Kuivanen S, Sirnonen T, Joensuu M, Vapalahti O, Kirchhausen T, Kipar A, Balistreri G. Kant R, et al. Among authors: balistreri g. bioRxiv [Preprint]. 2023 Jul 20:2023.07.19.549731. doi: 10.1101/2023.07.19.549731. bioRxiv. 2023. PMID: 37503261 Free PMC article. Preprint.
Human-derived air-liquid interface cultures decipher Alzheimer's disease-SARS-CoV-2 crosstalk in the olfactory mucosa.
Shahbaz MA, Kuivanen S, Lampinen R, Mussalo L, Hron T, Závodná T, Ojha R, Krejčík Z, Saveleva L, Tahir NA, Kalapudas J, Koivisto AM, Penttilä E, Löppönen H, Singh P, Topinka J, Vapalahti O, Chew S, Balistreri G, Kanninen KM. Shahbaz MA, et al. Among authors: balistreri g. J Neuroinflammation. 2023 Dec 14;20(1):299. doi: 10.1186/s12974-023-02979-4. J Neuroinflammation. 2023. PMID: 38098019 Free PMC article.
The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses.
Bigotti MG, Klein K, Gan ES, Anastasina M, Andersson S, Vapalahti O, Katajisto P, Erdmann M, Davidson AD, Butcher SJ, Collinson I, Ooi EE, Balistreri G, Brancaccio A, Yamauchi Y. Bigotti MG, et al. Among authors: balistreri g. Antiviral Res. 2024 Apr;224:105837. doi: 10.1016/j.antiviral.2024.105837. Epub 2024 Feb 20. Antiviral Res. 2024. PMID: 38387750 Free article.
40 results