Balakrishnan B - Search Results

1

Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.

Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S. Liu L, et al. Among authors: balakrishnan b. J Med Chem. 2021 Sep 23;64(18):13551-13571. doi: 10.1021/acs.jmedchem.1c00945. Epub 2021 Sep 7. J Med Chem. 2021. PMID: 34491744 Free PMC article.

2

Galactose-1 phosphate uridylyltransferase (GalT) gene: A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts.

Balakrishnan B, Chen W, Tang M, Huang X, Cakici DD, Siddiqi A, Berry G, Lai K. Balakrishnan B, et al. Biochem Biophys Res Commun. 2016 Jan 29;470(1):205-212. doi: 10.1016/j.bbrc.2016.01.036. Epub 2016 Jan 8. Biochem Biophys Res Commun. 2016. PMID: 26773505 Free PMC article.

3

Assessment of ataxia phenotype in a new mouse model of galactose-1 phosphate uridylyltransferase (GALT) deficiency.

Chen W, Caston R, Balakrishnan B, Siddiqi A, Parmar K, Tang M, Feng M, Lai K. Chen W, et al. Among authors: balakrishnan b. J Inherit Metab Dis. 2017 Jan;40(1):131-137. doi: 10.1007/s10545-016-9993-2. Epub 2016 Oct 25. J Inherit Metab Dis. 2017. PMID: 27783170 Free PMC article.

4

Reversal of aberrant PI3K/Akt signaling by Salubrinal in a GalT-deficient mouse model.

Balakrishnan B, Nicholas C, Siddiqi A, Chen W, Bales E, Feng M, Johnson J, Lai K. Balakrishnan B, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3286-3293. doi: 10.1016/j.bbadis.2017.08.023. Epub 2017 Aug 26. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28844959 Free article.

5

Effect of genotype on galactose-1-phosphate in classic galactosemia patients.

Yuzyuk T, Balakrishnan B, Schwarz EL, De Biase I, Hobert J, Longo N, Mao R, Lai K, Pasquali M. Yuzyuk T, et al. Among authors: balakrishnan b. Mol Genet Metab. 2018 Nov;125(3):258-265. doi: 10.1016/j.ymgme.2018.08.012. Epub 2018 Aug 23. Mol Genet Metab. 2018. PMID: 30172461

6

A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality.

Balakrishnan B, Verheijen J, Lupo A, Raymond K, Turgeon C, Yang Y, Carter KL, Whitehead KJ, Kozicz T, Morava E, Lai K. Balakrishnan B, et al. J Inherit Metab Dis. 2019 Sep;42(5):998-1007. doi: 10.1002/jimd.12110. Epub 2019 Jun 21. J Inherit Metab Dis. 2019. PMID: 31077402 Free PMC article.

7

Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia.

Balakrishnan B, Siddiqi A, Mella J, Lupo A, Li E, Hollien J, Johnson J, Lai K. Balakrishnan B, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165516. doi: 10.1016/j.bbadis.2019.07.010. Epub 2019 Jul 27. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31362041 Free PMC article.

8

Novel mRNA-Based Therapy Reduces Toxic Galactose Metabolites and Overcomes Galactose Sensitivity in a Mouse Model of Classic Galactosemia.

Balakrishnan B, An D, Nguyen V, DeAntonis C, Martini PGV, Lai K. Balakrishnan B, et al. Mol Ther. 2020 Jan 8;28(1):304-312. doi: 10.1016/j.ymthe.2019.09.018. Epub 2019 Sep 19. Mol Ther. 2020. PMID: 31604675 Free PMC article.

9

AAV9-based PMM2 gene replacement augments PMM2 expression and improves glycosylation in primary fibroblasts of patients with phosphomannomutase 2 deficiency (PMM2-CDG).

Zhong M, Balakrishnan B, Guo AJ, Lai K. Zhong M, et al. Among authors: balakrishnan b. Mol Genet Metab Rep. 2023 Dec 16;38:101035. doi: 10.1016/j.ymgmr.2023.101035. eCollection 2024 Mar. Mol Genet Metab Rep. 2023. PMID: 38130891 Free PMC article.

10

Whole-body galactose oxidation as a robust functional assay to assess the efficacy of gene-based therapies in a mouse model of Galactosemia.

Balakrishnan B, Yan X, McCue MD, Bellagamba O, Guo A, Winkler F, Thall J, Crawford L, Dimen R, Chen S, McEnaney S, Wu Y, Zimmer M, Sarkis J, Martini PGV, Finn PF, Lai K. Balakrishnan B, et al. Mol Ther Methods Clin Dev. 2024 Jan 17;32(1):101191. doi: 10.1016/j.omtm.2024.101191. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38352271 Free PMC article.

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