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Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.
Bermejo M, Paixão P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Löbenberg R, Lee A, Frances A, Amidon GE, Yu A, Salehi N, Talattof A, Benninghoff G, Sun D, Kuminek G, Cavanagh KL, Rodríguez-Hornedo N, Amidon GL. Bermejo M, et al. Among authors: baker jr. Mol Pharm. 2018 Dec 3;15(12):5454-5467. doi: 10.1021/acs.molpharmaceut.8b00515. Epub 2018 Nov 12. Mol Pharm. 2018. PMID: 30372084 Free PMC article. Clinical Trial.
Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract.
Yu A, Baker JR, Fioritto AF, Wang Y, Luo R, Li S, Wen B, Bly M, Tsume Y, Koenigsknecht MJ, Zhang X, Lionberger R, Amidon GL, Hasler WL, Sun D. Yu A, et al. Among authors: baker jr. Mol Pharm. 2017 Feb 6;14(2):345-358. doi: 10.1021/acs.molpharmaceut.6b00641. Epub 2016 Dec 23. Mol Pharm. 2017. PMID: 28009518
Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.
Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Loebenberg R, Lee A, Frances A, Amidon G, Yu A, Benninghoff G, Salehi N, Talattof A, Sun D, Amidon GL. Hens B, et al. Among authors: baker jr. Mol Pharm. 2017 Dec 4;14(12):4281-4294. doi: 10.1021/acs.molpharmaceut.7b00426. Epub 2017 Aug 4. Mol Pharm. 2017. PMID: 28737409 Clinical Trial.
In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions.
Koenigsknecht MJ, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai MP, Bleske BE, Zhang X, Lionberger R, Lee A, Amidon GL, Hasler WL, Sun D. Koenigsknecht MJ, et al. Among authors: baker jr. Mol Pharm. 2017 Dec 4;14(12):4295-4304. doi: 10.1021/acs.molpharmaceut.7b00425. Epub 2017 Oct 5. Mol Pharm. 2017. PMID: 28937221 Free PMC article. Clinical Trial.
Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach.
Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Löbenberg R, Talattof A, Sun D, Amidon GL. Paixão P, et al. Among authors: baker jr. Eur J Pharm Biopharm. 2018 Aug;129:162-174. doi: 10.1016/j.ejpb.2018.05.033. Epub 2018 May 29. Eur J Pharm Biopharm. 2018. PMID: 29857136 Free PMC article. Clinical Trial.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.
Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Löbenberg R, Talattof A, Sun D, Amidon GL. Paixão P, et al. Among authors: baker jr. Mol Pharm. 2018 Dec 3;15(12):5468-5478. doi: 10.1021/acs.molpharmaceut.8b00736. Epub 2018 Nov 12. Mol Pharm. 2018. PMID: 30417648 Free PMC article. Clinical Trial.
Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications.
Augustijns P, Vertzoni M, Reppas C, Langguth P, Lennernäs H, Abrahamsson B, Hasler WL, Baker JR, Vanuytsel T, Tack J, Corsetti M, Bermejo M, Paixão P, Amidon GL, Hens B. Augustijns P, et al. Among authors: baker jr. Eur J Pharm Sci. 2020 Dec 1;155:105517. doi: 10.1016/j.ejps.2020.105517. Epub 2020 Aug 18. Eur J Pharm Sci. 2020. PMID: 32818656 Free article. Review.
Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.
Heissam K, Abrehart N, Hoad CL, Wright J, Menys A, Murray K, Glover PM, Hebbard G, Gowland PA, Baker J, Hasler WL, Spiller RC, Corsetti M, Brasseur JG, Hens B, Shedden K, Dickens J, Mudie DM, Amidon GE, Amidon GL, Marciani L. Heissam K, et al. PLoS One. 2020 Nov 11;15(11):e0241441. doi: 10.1371/journal.pone.0241441. eCollection 2020. PLoS One. 2020. PMID: 33175860 Free PMC article. Clinical Trial.
1,642 results