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Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Jernigan F, Branstrom A, Baird JD, Cao L, Dali M, Furia B, Kim MJ, O'Keefe K, Kong R, Laskin OL, Colacino JM, Pykett M, Mollin A, Sheedy J, Dumble M, Moon YC, Sheridan R, Mühlethaler T, Spiegel RJ, Prota AE, Steinmetz MO, Weetall M. Jernigan F, et al. Among authors: baird jd. Mol Cancer Ther. 2021 Oct;20(10):1846-1857. doi: 10.1158/1535-7163.MCT-20-0774. Epub 2021 Jul 26. Mol Cancer Ther. 2021. PMID: 34315764 Free PMC article. Clinical Trial.
4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis.
Arnold MA, Gerasyuto AI, Wang J, Du W, Gorske YJK, Arasu T, Baird J, Almstead NG, Narasimhan J, Peddi S, Ginzburg O, Lue SW, Hedrick J, Sheedy J, Lagaud G, Branstrom AA, Weetall M, Prasad JVNV, Karp GM. Arnold MA, et al. Bioorg Med Chem Lett. 2017 Nov 15;27(22):5014-5021. doi: 10.1016/j.bmcl.2017.10.006. Epub 2017 Oct 5. Bioorg Med Chem Lett. 2017. PMID: 29032026
Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.
Gerasyuto AI, Arnold MA, Wang J, Chen G, Zhang X, Smith S, Woll MG, Baird J, Zhang N, Almstead NG, Narasimhan J, Peddi S, Dumble M, Sheedy J, Weetall M, Branstrom AA, Prasad JVN, Karp GM. Gerasyuto AI, et al. J Med Chem. 2018 May 24;61(10):4456-4475. doi: 10.1021/acs.jmedchem.8b00114. Epub 2018 May 14. J Med Chem. 2018. PMID: 29727185 Free PMC article.
Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer.
Buechel M, Dey A, Dwivedi SKD, Crim A, Ding K, Zhang R, Mukherjee P, Moore KN, Cao L, Branstrom A, Weetall M, Baird J, Bhattacharya R. Buechel M, et al. Mol Cancer Ther. 2018 Oct;17(10):2136-2143. doi: 10.1158/1535-7163.MCT-17-1192. Epub 2018 Jul 19. Mol Cancer Ther. 2018. PMID: 30026381 Free PMC article.
Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria.
Gerasyuto AI, Arnold MA, Wang J, Chen G, Zhang X, Smith S, Woll MG, Baird J, Zhang N, Almstead NG, Narasimhan J, Peddi S, Dumble M, Sheedy J, Weetall M, Branstrom AA, Prasad JVN, Karp GM. Gerasyuto AI, et al. J Med Chem. 2018 Oct 25;61(20):9394. doi: 10.1021/acs.jmedchem.8b01538. Epub 2018 Oct 16. J Med Chem. 2018. PMID: 30351051 Free PMC article. No abstract available.
Pharmacokinetics and Safety of PTC596, a Novel Tubulin-Binding Agent, in Subjects With Advanced Solid Tumors.
Shapiro GI, O'Mara E, Laskin OL, Gao L, Baird JD, Spiegel RJ, Kaushik D, Weetall M, Colacino J, O'Keefe K, Branstrom A, Goodwin E, Infante J, Bedard PL, Kong R. Shapiro GI, et al. Among authors: baird jd. Clin Pharmacol Drug Dev. 2021 Aug;10(8):940-949. doi: 10.1002/cpdd.904. Epub 2021 Jan 13. Clin Pharmacol Drug Dev. 2021. PMID: 33440067 Clinical Trial.
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia.
Branstrom A, Cao L, Furia B, Trotta C, Santaguida M, Graci JD, Colacino JM, Ray B, Li W, Sheedy J, Mollin A, Yeh S, Kong R, Sheridan R, Baird JD, O'Keefe K, Spiegel R, Goodwin E, Keating S, Weetall M. Branstrom A, et al. Among authors: baird jd. Front Oncol. 2022 Feb 9;12:832816. doi: 10.3389/fonc.2022.832816. eCollection 2022. Front Oncol. 2022. PMID: 35223511 Free PMC article.
Targeting BMI1 mitigates chemoresistance in ovarian cancer.
Dey A, Dhar Dwivedi SK, Wang L, Hossen MN, Neizer-Ashun F, Bieniasz M, Mukherjee P, Baird JD, Weetall M, Bhattacharya R. Dey A, et al. Among authors: baird jd. Genes Dis. 2022 Mar 18;9(6):1415-1418. doi: 10.1016/j.gendis.2022.02.006. eCollection 2022 Nov. Genes Dis. 2022. PMID: 36157476 Free PMC article. No abstract available.
168 results