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The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups.
Baek SB, Bahn G, Moon SJ, Lee J, Kim KH, Ko IG, Kim SE, Sung YH, Kim BK, Kim TS, Kim CJ, Shin MS. Baek SB, et al. Neurosci Lett. 2011 Jan 13;488(1):26-30. doi: 10.1016/j.neulet.2010.10.074. Epub 2010 Nov 5. Neurosci Lett. 2011. PMID: 21056623
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