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Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders.
Baglaenko Y, Wagner C, Bhoj VG, Brodin P, Gershwin ME, Graham D, Invernizzi P, Kidd KK, Korsunsky I, Levy M, Mammen AL, Nizet V, Ramirez-Valle F, Stites EC, Williams MS, Wilson M, Rose NR, Ladd V, Sirota M. Baglaenko Y, et al. Camb Prism Precis Med. 2023 May 11;1:e25. doi: 10.1017/pcm.2023.14. eCollection 2023. Camb Prism Precis Med. 2023. PMID: 38550937 Free PMC article. Review.
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development.
Kim T, Martínez-Bonet M, Wang Q, Hackert N, Sparks JA, Baglaenko Y, Koh B, Darbousset R, Laza-Briviesca R, Chen X, Aguiar VRC, Chiu DJ, Westra HJ, Gutierrez-Arcelus M, Weirauch MT, Raychaudhuri S, Rao DA, Nigrovic PA. Kim T, et al. Among authors: baglaenko y. Nat Commun. 2024 Mar 9;15(1):2150. doi: 10.1038/s41467-024-46457-8. Nat Commun. 2024. PMID: 38459032 Free PMC article.
The intestinal microbiota modulates the transcriptional landscape of iNKT cells at steady-state and following antigen exposure.
Lin Q, Kuypers M, Baglaenko Y, Cao E, Hezaveh K, Despot T, de Amat Herbozo C, Cruz Tleugabulova M, Umaña JM, McGaha TL, Philpott DJ, Mallevaey T. Lin Q, et al. Among authors: baglaenko y. Mucosal Immunol. 2024 Apr;17(2):226-237. doi: 10.1016/j.mucimm.2024.02.002. Epub 2024 Feb 7. Mucosal Immunol. 2024. PMID: 38331095 Free article.
The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity.
Wang XF, Vigouroux R, Syonov M, Baglaenko Y, Nikolakopoulou AM, Ringuette D, Rus H, DiStefano PV, Dufour S, Shabanzadeh AP, Lee S, Mueller BK, Charish J, Harada H, Fish JE, Wither J, Wälchli T, Cloutier JF, Zlokovic BV, Carlen PL, Monnier PP. Wang XF, et al. Among authors: baglaenko y. Nat Commun. 2024 Feb 3;15(1):1037. doi: 10.1038/s41467-024-45303-1. Nat Commun. 2024. PMID: 38310100 Free PMC article.
Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin.
Xiao Q, Mears J, Nathan A, Ishigaki K, Baglaenko Y, Lim N, Cooney LA, Harris KM, Anderson MS, Fox DA, Smilek DE, Krueger JG, Raychaudhuri S. Xiao Q, et al. Among authors: baglaenko y. Nat Commun. 2023 Oct 7;14(1):6268. doi: 10.1038/s41467-023-41984-2. Nat Commun. 2023. PMID: 37805522 Free PMC article.
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.
Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S. Nathan A, et al. Among authors: baglaenko y. Nature. 2022 Jun;606(7912):120-128. doi: 10.1038/s41586-022-04713-1. Epub 2022 May 11. Nature. 2022. PMID: 35545678 Free PMC article.
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.
Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri S. Nathan A, et al. Among authors: baglaenko y. Nat Immunol. 2021 Jun;22(6):781-793. doi: 10.1038/s41590-021-00933-1. Epub 2021 May 24. Nat Immunol. 2021. PMID: 34031617 Free PMC article.
27 results