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Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex.
Sun Y, Baechler SA, Zhang X, Kumar S, Factor VM, Arakawa Y, Chau CH, Okamoto K, Parikh A, Walker B, Su YP, Chen J, Ting T, Huang SN, Beck E, Itkin Z, McKnight C, Xie C, Roper N, Nijhawan D, Figg WD, Meltzer PS, Yang JC, Thomas CJ, Pommier Y. Sun Y, et al. Among authors: baechler sa. Nat Commun. 2023 Jun 23;14(1):3762. doi: 10.1038/s41467-023-39374-9. Nat Commun. 2023. PMID: 37353483 Free PMC article.
Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.
Huang SN, Dalla Rosa I, Michaels SA, Tulumello DV, Agama K, Khiati S, Jean SR, Baechler SA, Factor VM, Varma S, Murai J, Miller Jenkins LM, Kelley SO, Pommier Y. Huang SN, et al. Among authors: baechler sa. EMBO Rep. 2018 Mar;19(3):e42139. doi: 10.15252/embr.201642139. Epub 2018 Feb 9. EMBO Rep. 2018. PMID: 29438979 Free PMC article.
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.
Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y. Khiati S, et al. Among authors: baechler sa. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11282-7. doi: 10.1073/pnas.1511016112. Epub 2015 Aug 24. Proc Natl Acad Sci U S A. 2015. PMID: 26305952 Free PMC article.
SLFN11 Blocks Stressed Replication Forks Independently of ATR.
Murai J, Tang SW, Leo E, Baechler SA, Redon CE, Zhang H, Al Abo M, Rajapakse VN, Nakamura E, Jenkins LMM, Aladjem MI, Pommier Y. Murai J, et al. Among authors: baechler sa. Mol Cell. 2018 Feb 1;69(3):371-384.e6. doi: 10.1016/j.molcel.2018.01.012. Mol Cell. 2018. PMID: 29395061 Free PMC article.
The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria.
Schultz CW, McCarthy GA, Nerwal T, Nevler A, DuHadaway JB, McCoy MD, Jiang W, Brown SZ, Goetz A, Jain A, Calvert VS, Vishwakarma V, Wang D, Preet R, Cassel J, Summer R, Shaghaghi H, Pommier Y, Baechler SA, Pishvaian MJ, Golan T, Yeo CJ, Petricoin EF, Prendergast GC, Salvino J, Singh PK, Dixon DA, Brody JR. Schultz CW, et al. Among authors: baechler sa. Mol Cancer Ther. 2021 Nov;20(11):2166-2176. doi: 10.1158/1535-7163.MCT-20-0652. Epub 2021 Aug 19. Mol Cancer Ther. 2021. PMID: 34413127 Free PMC article.
14 results