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Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma.
Kent LN, Bae S, Tsai SY, Tang X, Srivastava A, Koivisto C, Martin CK, Ridolfi E, Miller GC, Zorko SM, Plevris E, Hadjiyannis Y, Perez M, Nolan E, Kladney R, Westendorp B, de Bruin A, Fernandez S, Rosol TJ, Pohar KS, Pipas JM, Leone G. Kent LN, et al. Among authors: bae s. J Clin Invest. 2017 Mar 1;127(3):830-842. doi: 10.1172/JCI87583. Epub 2017 Jan 30. J Clin Invest. 2017. PMID: 28134624 Free PMC article.
E2f8 mediates tumor suppression in postnatal liver development.
Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G. Kent LN, et al. Among authors: bae s. J Clin Invest. 2016 Aug 1;126(8):2955-69. doi: 10.1172/JCI85506. Epub 2016 Jul 25. J Clin Invest. 2016. PMID: 27454291 Free PMC article.
Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.
Cuitiño MC, Pécot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G. Cuitiño MC, et al. Cell Rep. 2019 Jun 18;27(12):3547-3560.e5. doi: 10.1016/j.celrep.2019.05.004. Epub 2019 May 23. Cell Rep. 2019. PMID: 31130414 Free PMC article.
Canonical and atypical E2Fs regulate the mammalian endocycle.
Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G. Chen HZ, et al. Among authors: bae s. Nat Cell Biol. 2012 Nov;14(11):1192-202. doi: 10.1038/ncb2595. Epub 2012 Oct 14. Nat Cell Biol. 2012. PMID: 23064266 Free PMC article.
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.
Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, Bader GD, Schimmer A, Zacksenhaus E. Jones RA, et al. Among authors: bae s. J Clin Invest. 2016 Oct 3;126(10):3739-3757. doi: 10.1172/JCI81568. Epub 2016 Aug 29. J Clin Invest. 2016. PMID: 27571409 Free PMC article.
Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.
Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G. Liu H, et al. Among authors: bae s. Dev Cell. 2017 May 22;41(4):392-407.e6. doi: 10.1016/j.devcel.2017.04.024. Dev Cell. 2017. PMID: 28535374 Free PMC article.
Tissue-specific targeting of cell fate regulatory genes by E2f factors.
Julian LM, Liu Y, Pakenham CA, Dugal-Tessier D, Ruzhynsky V, Bae S, Tsai SY, Leone G, Slack RS, Blais A. Julian LM, et al. Among authors: bae s. Cell Death Differ. 2016 Apr;23(4):565-75. doi: 10.1038/cdd.2015.36. Epub 2015 Apr 24. Cell Death Differ. 2016. PMID: 25909886 Free PMC article.
L-2-hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. Kundu A, et al. Among authors: bae s. J Clin Invest. 2024 May 14:e171294. doi: 10.1172/JCI171294. Online ahead of print. J Clin Invest. 2024. PMID: 38743486
5,984 results