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IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.
Nachmias B, Khan DH, Voisin V, Mer AS, Thomas GE, Segev N, St-Germain J, Hurren R, Gronda M, Botham A, Wang X, Maclean N, Seneviratne AK, Duong N, Xu C, Arruda A, Orouji E, Algouneh A, Hakem R, Shlush L, Minden MD, Raught B, Bader GD, Schimmer AD. Nachmias B, et al. Among authors: bader gd. Leukemia. 2022 May;36(5):1283-1295. doi: 10.1038/s41375-022-01513-4. Epub 2022 Feb 12. Leukemia. 2022. PMID: 35152270 Free PMC article.
Attenuation of miR-126 activity expands HSC in vivo without exhaustion.
Lechman ER, Gentner B, van Galen P, Giustacchini A, Saini M, Boccalatte FE, Hiramatsu H, Restuccia U, Bachi A, Voisin V, Bader GD, Dick JE, Naldini L. Lechman ER, et al. Among authors: bader gd. Cell Stem Cell. 2012 Dec 7;11(6):799-811. doi: 10.1016/j.stem.2012.09.001. Epub 2012 Nov 8. Cell Stem Cell. 2012. PMID: 23142521 Free PMC article.
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G. Lee AY, et al. Among authors: bader gd. Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Science. 2014. PMID: 24723613 Free PMC article.
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD. Cole A, et al. Among authors: bader gd. Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004. Cancer Cell. 2015. PMID: 26058080 Free PMC article.
345 results