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Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Teng ACT, Gu L, Di Paola M, Lakin R, Williams ZJ, Au A, Chen W, Callaghan NI, Zadeh FH, Zhou YQ, Fatah M, Chatterjee D, Jourdan LJ, Liu J, Simmons CA, Kislinger T, Yip CM, Backx PH, Gourdie RG, Hamilton RM, Gramolini AO. Teng ACT, et al. Among authors: backx ph. Nat Commun. 2022 Oct 18;13(1):6166. doi: 10.1038/s41467-022-33303-y. Nat Commun. 2022. PMID: 36257954 Free PMC article.
Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.
Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH. Gramolini AO, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2446-51. doi: 10.1073/pnas.0510883103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461894 Free PMC article.
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.
Trivieri MG, Oudit GY, Sah R, Kerfant BG, Sun H, Gramolini AO, Pan Y, Wickenden AD, Croteau W, Morreale de Escobar G, Pekhletski R, St Germain D, Maclennan DH, Backx PH. Trivieri MG, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6043-8. doi: 10.1073/pnas.0601072103. Epub 2006 Apr 4. Proc Natl Acad Sci U S A. 2006. PMID: 16595628 Free PMC article.
Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.
Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, Seidman JG, Seidman CE, Frey B, Perry M, Backx PH, Liu PP, MacLennan DH, Emili A. Gramolini AO, et al. Among authors: backx ph. Mol Cell Proteomics. 2008 Mar;7(3):519-33. doi: 10.1074/mcp.M700245-MCP200. Epub 2007 Nov 30. Mol Cell Proteomics. 2008. PMID: 18056057 Free article.
Tbx5-dependent pathway regulating diastolic function in congenital heart disease.
Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. Zhu Y, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5519-24. doi: 10.1073/pnas.0801779105. Epub 2008 Mar 31. Proc Natl Acad Sci U S A. 2008. PMID: 18378906 Free PMC article.
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO. Bousette N, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. doi: 10.1073/pnas.1013555107. Epub 2010 Oct 11. Proc Natl Acad Sci U S A. 2010. PMID: 20937869 Free PMC article.
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes.
Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Massé S, Gagliardi M, Hsieh A, Thavandiran N, Laflamme MA, Nanthakumar K, Gross GJ, Backx PH, Keller G, Radisic M. Nunes SS, et al. Among authors: backx ph. Nat Methods. 2013 Aug;10(8):781-7. doi: 10.1038/nmeth.2524. Epub 2013 Jun 23. Nat Methods. 2013. PMID: 23793239 Free PMC article.
Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.
Strandberg LS, Cui X, Rath A, Liu J, Silverman ED, Liu X, Siragam V, Ackerley C, Su BB, Yan JY, Capecchi M, Biavati L, Accorroni A, Yuen W, Quattrone F, Lung K, Jaeggi ET, Backx PH, Deber CM, Hamilton RM. Strandberg LS, et al. Among authors: backx ph. PLoS One. 2013 Sep 9;8(9):e72668. doi: 10.1371/journal.pone.0072668. eCollection 2013. PLoS One. 2013. PMID: 24039792 Free PMC article.
226 results