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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch M, Schraft L, Chan A, Küchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Krämer C, Clauder-Münster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D, Steinmetz LM. Grosch M, et al. Among authors: backs j. Nat Commun. 2023 Jun 22;14(1):3714. doi: 10.1038/s41467-023-39352-1. Nat Commun. 2023. PMID: 37349314 Free PMC article.
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. Backs J, et al. Among authors: backs t. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. doi: 10.1073/pnas.0813013106. Epub 2009 Jan 28. Proc Natl Acad Sci U S A. 2009. PMID: 19179290 Free PMC article.
141 results