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Loss of CASK Accelerates Heart Failure Development.
Mustroph J, Sag CM, Bähr F, Schmidtmann AL, Gupta SN, Dietz A, Islam MMT, Lücht C, Beuthner BE, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, Lehrke M, Marx N, Mohler PJ, Bers DM, Unsöld B, He T, Dewenter M, Backs J, Maier LS, Wagner S. Mustroph J, et al. Among authors: backs j. Circ Res. 2021 Apr 16;128(8):1139-1155. doi: 10.1161/CIRCRESAHA.120.318170. Epub 2021 Feb 17. Circ Res. 2021. PMID: 33593074 Free PMC article.
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. Backs J, et al. Among authors: backs t. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. doi: 10.1073/pnas.0813013106. Epub 2009 Jan 28. Proc Natl Acad Sci U S A. 2009. PMID: 19179290 Free PMC article.
Differential cardiac remodeling in preload versus afterload.
Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G. Toischer K, et al. Among authors: backs j. Circulation. 2010 Sep 7;122(10):993-1003. doi: 10.1161/CIRCULATIONAHA.110.943431. Epub 2010 Aug 23. Circulation. 2010. PMID: 20733099 Free PMC article.
The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21.
Li W, Li H, Sanders PN, Mohler PJ, Backs J, Olson EN, Anderson ME, Grumbach IM. Li W, et al. Among authors: backs j. J Biol Chem. 2011 Mar 11;286(10):7990-7999. doi: 10.1074/jbc.M110.163006. Epub 2010 Dec 30. J Biol Chem. 2011. PMID: 21193397 Free PMC article.
Reversibility of adverse, calcineurin-dependent cardiac remodeling.
Berry JM, Le V, Rotter D, Battiprolu PK, Grinsfelder B, Tannous P, Burchfield JS, Czubryt M, Backs J, Olson EN, Rothermel BA, Hill JA. Berry JM, et al. Among authors: backs j. Circ Res. 2011 Aug 5;109(4):407-17. doi: 10.1161/CIRCRESAHA.110.228452. Epub 2011 Jun 23. Circ Res. 2011. PMID: 21700928 Free PMC article.
F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.
Spaich S, Will RD, Just S, Spaich S, Kuhn C, Frank D, Berger IM, Wiemann S, Korn B, Koegl M, Backs J, Katus HA, Rottbauer W, Frey N. Spaich S, et al. Among authors: backs j. Circ Res. 2012 Dec 7;111(12):1504-16. doi: 10.1161/CIRCRESAHA.112.271007. Epub 2012 Sep 12. Circ Res. 2012. PMID: 22972877
141 results