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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.
Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA. Orth-He EL, et al. Among authors: bachovchin da. Cell Rep. 2023 Jan 31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649711 Free PMC article.
Quantitative reactivity profiling predicts functional cysteines in proteomes.
Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. Weerapana E, et al. Among authors: bachovchin da. Nature. 2010 Dec 9;468(7325):790-5. doi: 10.1038/nature09472. Epub 2010 Nov 17. Nature. 2010. PMID: 21085121 Free PMC article.
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.
Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE, Kiritsy CP, Healey SE, DiMare M, Sanford DG, Munford RS, Bachovchin WW, Golub TR. Bachovchin DA, et al. Among authors: bachovchin ww. Nat Chem Biol. 2014 Aug;10(8):656-63. doi: 10.1038/nchembio.1578. Epub 2014 Jul 6. Nat Chem Biol. 2014. PMID: 24997602 Free PMC article.
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
Okondo MC, Johnson DC, Sridharan R, Go EB, Chui AJ, Wang MS, Poplawski SE, Wu W, Liu Y, Lai JH, Sanford DG, Arciprete MO, Golub TR, Bachovchin WW, Bachovchin DA. Okondo MC, et al. Among authors: bachovchin da, bachovchin ww. Nat Chem Biol. 2017 Jan;13(1):46-53. doi: 10.1038/nchembio.2229. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820798 Free PMC article.
Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.
Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Okondo MC, et al. Among authors: bachovchin da. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. Cell Chem Biol. 2018. PMID: 29396289 Free PMC article.
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA. Johnson DC, et al. Among authors: bachovchin da. Nat Med. 2018 Aug;24(8):1151-1156. doi: 10.1038/s41591-018-0082-y. Epub 2018 Jul 2. Nat Med. 2018. PMID: 29967349 Free PMC article.
N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA. Chui AJ, et al. Among authors: bachovchin da. Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14. Science. 2019. PMID: 30872531 Free PMC article.
A Chemical Strategy for Protease Substrate Profiling.
Griswold AR, Cifani P, Rao SD, Axelrod AJ, Miele MM, Hendrickson RC, Kentsis A, Bachovchin DA. Griswold AR, et al. Among authors: bachovchin da. Cell Chem Biol. 2019 Jun 20;26(6):901-907.e6. doi: 10.1016/j.chembiol.2019.03.007. Epub 2019 Apr 18. Cell Chem Biol. 2019. PMID: 31006619 Free PMC article.
61 results