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Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán Peninsula.
Pech-Puch D, Forero AM, Fuentes-Monteverde JC, Lasarte-Monterrubio C, Martinez-Guitian M, González-Salas C, Guillén-Hernández S, Villegas-Hernández H, Beceiro A, Griesinger C, Rodríguez J, Jiménez C. Pech-Puch D, et al. Mar Drugs. 2022 Apr 28;20(5):298. doi: 10.3390/md20050298. Mar Drugs. 2022. PMID: 35621949 Free PMC article.
Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and (+)-agelasidine C (6), were isolated from the sponge Agelas citrina, …
Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with t …
In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa.
Pech-Puch D, Pérez-Povedano M, Martinez-Guitian M, Lasarte-Monterrubio C, Vázquez-Ucha JC, Bou G, Rodríguez J, Beceiro A, Jimenez C. Pech-Puch D, et al. Mar Drugs. 2020 Jun 23;18(6):326. doi: 10.3390/md18060326. Mar Drugs. 2020. PMID: 32585891 Free PMC article.
We also evaluated, for the first time, the activity of these alkaloids against the most problematic multidrug-resistant (MDR) pathogens, i.e., the Gram-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Bromoageliferin (2) displaye …
We also evaluated, for the first time, the activity of these alkaloids against the most problematic multidrug-resistant (MDR) pathogens, i. …