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Year | Number of Results |
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Page 1
Minimum Information about a Biosynthetic Gene cluster.
Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890.
Nat Chem Biol. 2015.
PMID: 26284661
Free PMC article.
No abstract available.
Biosynthesis of mupirocin by Pseudomonas fluorescens NCIMB 10586 involves parallel pathways.
Gao SS, Hothersall J, Wu J, Murphy AC, Song Z, Stephens ER, Thomas CM, Crump MP, Cox RJ, Simpson TJ, Willis CL.
Gao SS, et al.
J Am Chem Soc. 2014 Apr 9;136(14):5501-7. doi: 10.1021/ja501731p. Epub 2014 Mar 27.
J Am Chem Soc. 2014.
PMID: 24625190
Item in Clipboard
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.
Hothersall J, Murphy AC, Iqbal Z, Campbell G, Stephens ER, Wu J, Cooper H, Atkinson S, Williams P, Crosby J, Willis CL, Cox RJ, Simpson TJ, Thomas CM.
Hothersall J, et al.
Appl Microbiol Biotechnol. 2011 May;90(3):1017-26. doi: 10.1007/s00253-011-3145-2. Epub 2011 Feb 12.
Appl Microbiol Biotechnol. 2011.
PMID: 21318358
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In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.
Lopanik NB, Shields JA, Buchholz TJ, Rath CM, Hothersall J, Haygood MG, Håkansson K, Thomas CM, Sherman DH.
Lopanik NB, et al.
Chem Biol. 2008 Nov 24;15(11):1175-86. doi: 10.1016/j.chembiol.2008.09.013.
Chem Biol. 2008.
PMID: 19022178
Free PMC article.
Item in Clipboard
In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.
Wu J, Hothersall J, Mazzetti C, O'Connell Y, Shields JA, Rahman AS, Cox RJ, Crosby J, Simpson TJ, Thomas CM, Willis CL.
Wu J, et al.
Chembiochem. 2008 Jun 16;9(9):1500-8. doi: 10.1002/cbic.200800085.
Chembiochem. 2008.
PMID: 18465759
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Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A.
Hothersall J, Wu J, Rahman AS, Shields JA, Haddock J, Johnson N, Cooper SM, Stephens ER, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM.
Hothersall J, et al.
J Biol Chem. 2007 May 25;282(21):15451-61. doi: 10.1074/jbc.M701490200. Epub 2007 Mar 23.
J Biol Chem. 2007.
PMID: 17383964
Free article.
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Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.
Cooper SM, Laosripaiboon W, Rahman AS, Hothersall J, El-Sayed AK, Winfield C, Crosby J, Cox RJ, Simpson TJ, Thomas CM.
Cooper SM, et al.
Chem Biol. 2005 Jul;12(7):825-33. doi: 10.1016/j.chembiol.2005.05.015.
Chem Biol. 2005.
PMID: 16039529
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