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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Q Do K, Halliez S, Bezzi P, Buée L, Leuba G, Colin M, Toni N, Déglon N. Richetin K, et al. Among authors: begard s. Nat Neurosci. 2020 Dec;23(12):1567-1579. doi: 10.1038/s41593-020-00728-x. Epub 2020 Nov 9. Nat Neurosci. 2020. PMID: 33169029
Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis.
Delobel P, Flament S, Hamdane M, Mailliot C, Sambo AV, Bégard S, Sergeant N, Delacourte A, Vilain JP, Buée L. Delobel P, et al. Among authors: begard s. J Neurochem. 2002 Oct;83(2):412-20. doi: 10.1046/j.1471-4159.2002.01143.x. J Neurochem. 2002. PMID: 12423251 Free article.
Pin1: a therapeutic target in Alzheimer neurodegeneration.
Hamdane M, Smet C, Sambo AV, Leroy A, Wieruszeski JM, Delobel P, Maurage CA, Ghestem A, Wintjens R, Bégard S, Sergeant N, Delacourte A, Horvath D, Landrieu I, Lippens G, Buée L. Hamdane M, et al. Among authors: begard s. J Mol Neurosci. 2002 Dec;19(3):275-87. doi: 10.1385/JMN:19:3:275. J Mol Neurosci. 2002. PMID: 12540053
Pin1 allows for differential Tau dephosphorylation in neuronal cells.
Hamdane M, Dourlen P, Bretteville A, Sambo AV, Ferreira S, Ando K, Kerdraon O, Bégard S, Geay L, Lippens G, Sergeant N, Delacourte A, Maurage CA, Galas MC, Buée L. Hamdane M, et al. Among authors: begard s. Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60. doi: 10.1016/j.mcn.2006.03.006. Epub 2006 May 11. Mol Cell Neurosci. 2006. PMID: 16697218
38 results