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SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Lospinoso Severini L, Loricchio E, Navacci S, Basili I, Alfonsi R, Bernardi F, Moretti M, Conenna M, Cucinotta A, Coni S, Petroni M, De Smaele E, Giannini G, Maroder M, Canettieri G, Mastronuzzi A, Guardavaccaro D, Ayrault O, Infante P, Bufalieri F, Di Marcotullio L. Lospinoso Severini L, et al. Among authors: ayrault o. Cell Death Differ. 2024 Feb;31(2):170-187. doi: 10.1038/s41418-023-01246-6. Epub 2023 Dec 7. Cell Death Differ. 2024. PMID: 38062245 Free PMC article.
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.
Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L. Bufalieri F, et al. Among authors: ayrault o. Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0. Nat Commun. 2019. PMID: 31341163 Free PMC article.
Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma.
Morfouace M, Shelat A, Jacus M, Freeman BB 3rd, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, Guy RK, Stewart CF, Gajjar A, Roussel MF. Morfouace M, et al. Among authors: ayrault o. Cancer Cell. 2014 Apr 14;25(4):516-29. doi: 10.1016/j.ccr.2014.02.009. Epub 2014 Mar 27. Cancer Cell. 2014. PMID: 24684846 Free PMC article.
Germline Elongator mutations in Sonic Hedgehog medulloblastoma.
Waszak SM, Robinson GW, Gudenas BL, Smith KS, Forget A, Kojic M, Garcia-Lopez J, Hadley J, Hamilton KV, Indersie E, Buchhalter I, Kerssemakers J, Jäger N, Sharma T, Rausch T, Kool M, Sturm D, Jones DTW, Vasilyeva A, Tatevossian RG, Neale G, Lombard B, Loew D, Nakitandwe J, Rusch M, Bowers DC, Bendel A, Partap S, Chintagumpala M, Crawford J, Gottardo NG, Smith A, Dufour C, Rutkowski S, Eggen T, Wesenberg F, Kjaerheim K, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Remke M, Puget S, Pajtler KW, Milde T, Witt O, Ryzhova M, Korshunov A, Orr BA, Ellison DW, Brugieres L, Lichter P, Nichols KE, Gajjar A, Wainwright BJ, Ayrault O, Korbel JO, Northcott PA, Pfister SM. Waszak SM, et al. Among authors: ayrault o. Nature. 2020 Apr;580(7803):396-401. doi: 10.1038/s41586-020-2164-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296180 Free PMC article.
Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.
Rickert D, Bartl J, Picard D, Bernardi F, Qin N, Lovino M, Puget S, Meyer FD, Mahoungou Koumba I, Beez T, Varlet P, Dufour C, Fischer U, Borkhardt A, Reifenberger G, Ayrault O, Remke M. Rickert D, et al. Among authors: ayrault o. Acta Neuropathol. 2021 Jun;141(6):975-978. doi: 10.1007/s00401-021-02306-2. Epub 2021 Apr 17. Acta Neuropathol. 2021. PMID: 33866410 Free PMC article. No abstract available.
Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma.
Pereira V, Torrejon J, Kariyawasam D, Berlanga P, Guerrini-Rousseau L, Ayrault O, Varlet P, Tauziède-Espariat A, Puget S, Bolle S, Beccaria K, Blauwblomme T, Brugières L, Grill J, Geoerger B, Dufour C, Abbou S. Pereira V, et al. Among authors: ayrault o. Neurooncol Adv. 2021 Jul 7;3(1):vdab097. doi: 10.1093/noajnl/vdab097. eCollection 2021 Jan-Dec. Neurooncol Adv. 2021. PMID: 34409296 Free PMC article.
Immunohistochemistry as a tool to identify ELP1-associated medulloblastoma.
Tauziède-Espariat A, Guerrini-Rousseau L, Perrier A, Torrejon J, Bernardi F, Varlet P, Hasty L, Delattre O, Beccaria K, Métais A, Ayrault O, Chrétien F, Bourdeaut F, Dufour C, Masliah-Planchon J. Tauziède-Espariat A, et al. Among authors: ayrault o. Acta Neuropathol. 2022 Apr;143(4):523-525. doi: 10.1007/s00401-022-02409-4. Epub 2022 Feb 23. Acta Neuropathol. 2022. PMID: 35199222 Free PMC article. No abstract available.
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
Bartl J, Zanini M, Bernardi F, Forget A, Blümel L, Talbot J, Picard D, Qin N, Cancila G, Gao Q, Nath S, Koumba IM, Wolter M, Kuonen F, Langini M, Beez T, Munoz C, Pauck D, Marquardt V, Yu H, Souphron J, Korsch M, Mölders C, Berger D, Göbbels S, Meyer FD, Scheffler B, Rotblat B, Diederichs S, Ramaswamy V, Suzuki H, Oro A, Stühler K, Stefanski A, Fischer U, Leprivier G, Willbold D, Steger G, Buell A, Kool M, Lichter P, Pfister SM, Northcott PA, Taylor MD, Borkhardt A, Reifenberger G, Ayrault O, Remke M. Bartl J, et al. Among authors: ayrault o. Nat Commun. 2022 Jul 13;13(1):4061. doi: 10.1038/s41467-022-31574-z. Nat Commun. 2022. PMID: 35831316 Free PMC article.
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
Valinciute G, Ecker J, Selt F, Hielscher T, Sigaud R, Ridinger J, Thatikonda V, Gatzweiler C, Robinson S, Talbot J, Bernardi F, Picard D, Blattner-Johnson M, Schmid S, Jones DT, van Tilburg CM, Capper D, Kool M, Remke M, Oehme I, Pfister SM, Roussel MF, Ayrault O, Witt O, Milde T. Valinciute G, et al. Among authors: ayrault o. J Neurooncol. 2023 May;163(1):143-158. doi: 10.1007/s11060-023-04319-1. Epub 2023 May 15. J Neurooncol. 2023. PMID: 37183219 Free PMC article.
Insights into cerebellar development and medulloblastoma.
Bihannic L, Ayrault O. Bihannic L, et al. Among authors: ayrault o. Bull Cancer. 2016 Jan;103(1):30-40. doi: 10.1016/j.bulcan.2015.11.002. Epub 2015 Dec 11. Bull Cancer. 2016. PMID: 26688373 Review.
72 results