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JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway.
Curr Alzheimer Res. 2005 Jul;2(3):327-34. doi: 10.2174/1567205054367874.
Curr Alzheimer Res. 2005.
PMID: 15974898
Review.
JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.
Petit A, Pasini A, Alves Da Costa C, Ayral E, Hernandez JF, Dumanchin-Njock C, Phiel CJ, Marambaud P, Wilk S, Farzan M, Fulcrand P, Martinez J, Andrau D, Checler F.
Petit A, et al. Among authors: ayral e.
J Neurosci Res. 2003 Nov 1;74(3):370-7. doi: 10.1002/jnr.10747.
J Neurosci Res. 2003.
PMID: 14598313
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BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.
Andrau D, Dumanchin-Njock C, Ayral E, Vizzavona J, Farzan M, Boisbrun M, Fulcrand P, Hernandez JF, Martinez J, Lefranc-Jullien S, Checler F.
Andrau D, et al. Among authors: ayral e.
J Biol Chem. 2003 Jul 11;278(28):25859-66. doi: 10.1074/jbc.M302622200. Epub 2003 May 7.
J Biol Chem. 2003.
PMID: 12736275
Free article.
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Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.
Alves da Costa C, Ayral E, Hernandez JF, St George-Hyslop P, Checler F.
Alves da Costa C, et al. Among authors: ayral e.
J Neurochem. 2004 Aug;90(4):800-6. doi: 10.1111/j.1471-4159.2004.02512.x.
J Neurochem. 2004.
PMID: 15287885
Free article.
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Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
Sevalle J, et al. Among authors: ayral e.
J Neurochem. 2009 Jul;110(1):275-83. doi: 10.1111/j.1471-4159.2009.06131.x. Epub 2009 Apr 29.
J Neurochem. 2009.
PMID: 19457123
Free article.
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Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.
Ayral E, Gloanec P, Bergé G, de Nanteuil G, Mennecier P, Rupin A, Verbeuren TJ, Fulcrand P, Martinez J, Hernandez JF.
Ayral E, et al.
Bioorg Med Chem Lett. 2009 Mar 1;19(5):1386-91. doi: 10.1016/j.bmcl.2009.01.039. Epub 2009 Jan 19.
Bioorg Med Chem Lett. 2009.
PMID: 19181521
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Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors.
Liutkus M, Caijo F, Girard AL, Ayral E, Audinot V, Boutin JA, Renard P, Caignard DH, Dacquet C, Ktorza A, Mosset P, Grée R.
Liutkus M, et al. Among authors: ayral e.
J Enzyme Inhib Med Chem. 2010 Oct;25(5):653-72. doi: 10.3109/14756360903468171.
J Enzyme Inhib Med Chem. 2010.
PMID: 20518620
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