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Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.
Queiroz RF, Stanley CP, Wolhuter K, Kong SMY, Rajivan R, McKinnon N, Nguyen GTH, Roveri A, Guttzeit S, Eaton P, Donald WA, Ursini F, Winterbourn CC, Ayer A, Stocker R. Queiroz RF, et al. Among authors: ayer a. Nat Commun. 2021 Nov 16;12(1):6626. doi: 10.1038/s41467-021-26991-5. Nat Commun. 2021. PMID: 34785665 Free PMC article.
Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling.
De Blasio MJ, Huynh K, Qin C, Rosli S, Kiriazis H, Ayer A, Cemerlang N, Stocker R, Du XJ, McMullen JR, Ritchie RH. De Blasio MJ, et al. Among authors: ayer a. Free Radic Biol Med. 2015 Oct;87:137-47. doi: 10.1016/j.freeradbiomed.2015.04.028. Epub 2015 Apr 30. Free Radic Biol Med. 2015. PMID: 25937176
Heme Oxygenases in Cardiovascular Health and Disease.
Ayer A, Zarjou A, Agarwal A, Stocker R. Ayer A, et al. Physiol Rev. 2016 Oct;96(4):1449-508. doi: 10.1152/physrev.00003.2016. Physiol Rev. 2016. PMID: 27604527 Free PMC article. Review.
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.
Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y, Chadha P, Suarna C, Prysyazhna O, Scotcher J, Dunn LL, Prado FM, Nguyen N, Odiba JO, Baell JB, Stasch JP, Yamamoto Y, Di Mascio P, Eaton P, Payne RJ, Stocker R. Stanley CP, et al. Among authors: ayer a. Nature. 2019 Feb;566(7745):548-552. doi: 10.1038/s41586-019-0947-3. Epub 2019 Feb 13. Nature. 2019. PMID: 30760924
122 results