Avery LB - Search Results

1

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.

Avery LB, Wade J, Wang M, Tam A, King A, Piche-Nicholas N, Kavosi MS, Penn S, Cirelli D, Kurz JC, Zhang M, Cunningham O, Jones R, Fennell BJ, McDonnell B, Sakorafas P, Apgar J, Finlay WJ, Lin L, Bloom L, O'Hara DM. Avery LB, et al. MAbs. 2018 Feb/Mar;10(2):244-255. doi: 10.1080/19420862.2017.1417718. Epub 2018 Jan 29. MAbs. 2018. PMID: 29271699 Free PMC article.

2

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice.

Fan YY, Avery LB, Wang M, O'Hara DM, Leung S, Neubert H. Fan YY, et al. Among authors: avery lb. MAbs. 2016 Jul;8(5):848-53. doi: 10.1080/19420862.2016.1178436. Epub 2016 Apr 22. MAbs. 2016. PMID: 27104806 Free PMC article.

3

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.

Avery LB, Wang M, Kavosi MS, Joyce A, Kurz JC, Fan YY, Dowty ME, Zhang M, Zhang Y, Cheng A, Hua F, Jones HM, Neubert H, Polzer RJ, O'Hara DM. Avery LB, et al. MAbs. 2016 Aug-Sep;8(6):1064-78. doi: 10.1080/19420862.2016.1193660. Epub 2016 May 27. MAbs. 2016. PMID: 27232760 Free PMC article.

4

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.

Piche-Nicholas NM, Avery LB, King AC, Kavosi M, Wang M, O'Hara DM, Tchistiakova L, Katragadda M. Piche-Nicholas NM, et al. Among authors: avery lb. MAbs. 2018 Jan;10(1):81-94. doi: 10.1080/19420862.2017.1389355. Epub 2017 Nov 3. MAbs. 2018. PMID: 28991504 Free PMC article.

5

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach.

Betts A, Keunecke A, van Steeg TJ, van der Graaf PH, Avery LB, Jones H, Berkhout J. Betts A, et al. Among authors: avery lb. MAbs. 2018 Jul;10(5):751-764. doi: 10.1080/19420862.2018.1462429. Epub 2018 May 14. MAbs. 2018. PMID: 29634430 Free PMC article.

6

A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.

Jones HM, Zhang Z, Jasper P, Luo H, Avery LB, King LE, Neubert H, Barton HA, Betts AM, Webster R. Jones HM, et al. Among authors: avery lb. CPT Pharmacometrics Syst Pharmacol. 2019 Oct;8(10):738-747. doi: 10.1002/psp4.12461. Epub 2019 Sep 23. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31464379 Free PMC article.

7

Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison.

Lade JM, Avery LB, Bumpus NN. Lade JM, et al. Among authors: avery lb. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79. doi: 10.1128/AAC.01401-13. Epub 2013 Aug 5. Antimicrob Agents Chemother. 2013. PMID: 23917319 Free PMC article.

8

Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect.

Avery LB, Zarr MA, Bakshi RP, Siliciano RF, Hendrix CW. Avery LB, et al. AIDS Res Hum Retroviruses. 2013 Nov;29(11):1434-42. doi: 10.1089/AID.2013.0031. Epub 2013 May 22. AIDS Res Hum Retroviruses. 2013. PMID: 23601085 Free PMC article.

9

Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice.

Avery LB, Bumpus NN. Avery LB, et al. Mol Pharmacol. 2014 Jan;85(1):1-10. doi: 10.1124/mol.113.089755. Epub 2013 Oct 8. Mol Pharmacol. 2014. PMID: 24105977 Free PMC article.

10

Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid.

Avery LB, VanAusdall JL, Hendrix CW, Bumpus NN. Avery LB, et al. Drug Metab Dispos. 2013 Feb;41(2):422-9. doi: 10.1124/dmd.112.049601. Epub 2012 Nov 19. Drug Metab Dispos. 2013. PMID: 23166317 Free PMC article.

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