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Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Sabo KA, Albekioni E, Caliger D, Coleman NJ, Thornberg E, Avellaneda Matteo D, Komives EA, Silletti S, Sohl CD. Sabo KA, et al. Among authors: avellaneda matteo d. Biochemistry. 2023 Mar 21;62(6):1145-1159. doi: 10.1021/acs.biochem.2c00636. Epub 2023 Feb 28. Biochemistry. 2023. PMID: 36854124 Free PMC article.
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Mealka M, et al. Among authors: avellaneda matteo d. Nat Commun. 2024 May 6;15(1):3785. doi: 10.1038/s41467-024-48277-2. Nat Commun. 2024. PMID: 38710674 Free PMC article.