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Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.
Biochem J. 2018 Oct 22;475(20):3221-3238. doi: 10.1042/BCJ20180424.
Biochem J. 2018.
PMID: 30249606
Free PMC article.
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
Avellaneda Matteo D, Grunseth AJ, Gonzalez ER, Anselmo SL, Kennedy MA, Moman P, Scott DA, Hoang A, Sohl CD.
Avellaneda Matteo D, et al.
J Biol Chem. 2017 May 12;292(19):7971-7983. doi: 10.1074/jbc.M117.776179. Epub 2017 Mar 22.
J Biol Chem. 2017.
PMID: 28330869
Free PMC article.
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Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Sabo KA, Albekioni E, Caliger D, Coleman NJ, Thornberg E, Avellaneda Matteo D, Komives EA, Silletti S, Sohl CD.
Sabo KA, et al. Among authors: avellaneda matteo d.
Biochemistry. 2023 Mar 21;62(6):1145-1159. doi: 10.1021/acs.biochem.2c00636. Epub 2023 Feb 28.
Biochemistry. 2023.
PMID: 36854124
Free PMC article.
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Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD.
Mealka M, et al. Among authors: avellaneda matteo d.
Nat Commun. 2024 May 6;15(1):3785. doi: 10.1038/s41467-024-48277-2.
Nat Commun. 2024.
PMID: 38710674
Free PMC article.
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