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Loss of the mitochondrial citrate carrier, Slc25a1/CIC disrupts embryogenesis via 2-Hydroxyglutarate.
Kasprzyk-Pawelec A, Tan M, Phua YL, Rahhal R, McIntosh A, Fernandez H, Mosaoa R, Girgis M, Cheema A, Jiang L, Kroemer LF, Popratiloff A, Clarkson C, Kirmsa BM, Pearson GW, Glasgow E, Albanese C, Vockley J, Avantaggiati ML. Kasprzyk-Pawelec A, et al. Among authors: avantaggiati ml. bioRxiv [Preprint]. 2024 Feb 9:2023.07.18.549409. doi: 10.1101/2023.07.18.549409. bioRxiv. 2024. PMID: 37503155 Free PMC article. Preprint.
Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH.
Tan M, Mosaoa R, Graham GT, Kasprzyk-Pawelec A, Gadre S, Parasido E, Catalina-Rodriguez O, Foley P, Giaccone G, Cheema A, Kallakury B, Albanese C, Yi C, Avantaggiati ML. Tan M, et al. Among authors: avantaggiati ml. Cell Death Differ. 2020 Jul;27(7):2143-2157. doi: 10.1038/s41418-020-0491-6. Epub 2020 Jan 20. Cell Death Differ. 2020. PMID: 31959914 Free PMC article.
The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells.
Parasido E, Avetian GS, Naeem A, Graham G, Pishvaian M, Glasgow E, Mudambi S, Lee Y, Ihemelandu C, Choudhry M, Peran I, Banerjee PP, Avantaggiati ML, Bryant K, Baldelli E, Pierobon M, Liotta L, Petricoin E, Fricke ST, Sebastian A, Cozzitorto J, Loots GG, Kumar D, Byers S, Londin E, DiFeo A, Narla G, Winter J, Brody JR, Rodriguez O, Albanese C. Parasido E, et al. Among authors: avantaggiati ml. Mol Cancer Res. 2019 Sep;17(9):1815-1827. doi: 10.1158/1541-7786.MCR-19-0191. Epub 2019 Jun 4. Mol Cancer Res. 2019. PMID: 31164413 Free PMC article.
The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.
Fernandez HR, Gadre SM, Tan M, Graham GT, Mosaoa R, Ongkeko MS, Kim KA, Riggins RB, Parasido E, Petrini I, Pacini S, Cheema A, Varghese R, Ressom HW, Zhang Y, Albanese C, Üren A, Paige M, Giaccone G, Avantaggiati ML. Fernandez HR, et al. Among authors: avantaggiati ml. Cell Death Differ. 2018 Jul;25(7):1239-1258. doi: 10.1038/s41418-018-0101-z. Epub 2018 Apr 12. Cell Death Differ. 2018. PMID: 29651165 Free PMC article.
Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.
Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, Wang X, Cruz I, Berry D, Kallakury B, Mueller SC, Agostino SD, Blandino G, Avantaggiati ML, Chung FL. Aggarwal M, et al. Among authors: avantaggiati ml. Cell Death Differ. 2016 Oct;23(10):1615-27. doi: 10.1038/cdd.2016.48. Epub 2016 Jun 3. Cell Death Differ. 2016. PMID: 27258787 Free PMC article.
68 results