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Sirtuins as regulators of metabolism and healthspan.
Houtkooper RH, Pirinen E, Auwerx J. Houtkooper RH, et al. Among authors: auwerx j. Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):225-238. doi: 10.1038/nrm3293. Nat Rev Mol Cell Biol. 2012. PMID: 22395773 Free PMC article. Review.
ERRγ Preserves Brown Fat Innate Thermogenic Activity.
Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. Ahmadian M, et al. Among authors: auwerx j. Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061. Cell Rep. 2018. PMID: 29539415 Free PMC article.
Reduced oxidative capacity in macrophages results in systemic insulin resistance.
Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, Kim KS, Kim HJ, Kim CS, Lee CH, Williams RW, Kim H, Lee HK, Auwerx J, Shong M. Jung SB, et al. Among authors: auwerx j. Nat Commun. 2018 Apr 19;9(1):1551. doi: 10.1038/s41467-018-03998-z. Nat Commun. 2018. PMID: 29674655 Free PMC article.
Autophagy regulates lipid metabolism through selective turnover of NCoR1.
Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M. Saito T, et al. Among authors: auwerx j. Nat Commun. 2019 Apr 5;10(1):1567. doi: 10.1038/s41467-019-08829-3. Nat Commun. 2019. PMID: 30952864 Free PMC article.
Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression.
Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA. Rocha AL, et al. Among authors: auwerx j. Sci Adv. 2020 Dec 2;6(49):eabc6250. doi: 10.1126/sciadv.abc6250. Print 2020 Dec. Sci Adv. 2020. PMID: 33268375 Free PMC article.
626 results