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Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Dikalova AE, Pandey A, Xiao L, Arslanbaeva L, Sidorova T, Lopez MG, Billings FT 4th, Verdin E, Auwerx J, Harrison DG, Dikalov SI. Dikalova AE, et al. Among authors: auwerx j. Circ Res. 2020 Feb 14;126(4):439-452. doi: 10.1161/CIRCRESAHA.119.315767. Epub 2019 Dec 19. Circ Res. 2020. PMID: 31852393 Free PMC article.
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Gaul DS, Weber J, van Tits LJ, Sluka S, Pasterk L, Reiner MF, Calatayud N, Lohmann C, Klingenberg R, Pahla J, Vdovenko D, Tanner FC, Camici GG, Eriksson U, Auwerx J, Mach F, Windecker S, Rodondi N, Lüscher TF, Winnik S, Matter CM. Gaul DS, et al. Among authors: auwerx j. Cardiovasc Res. 2018 Jul 1;114(8):1178-1188. doi: 10.1093/cvr/cvy036. Cardiovasc Res. 2018. PMID: 29444200 Free PMC article.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.
Zhu X, Shen W, Yao K, Wang H, Liu B, Li T, Song L, Diao D, Mao G, Huang P, Li C, Zhang H, Zou Y, Qiu Y, Zhao Y, Wang W, Yang Y, Hu Z, Auwerx J, Loscalzo J, Zhou Y, Ju Z. Zhu X, et al. Among authors: auwerx j. Circ Res. 2019 Sep 13;125(7):707-719. doi: 10.1161/CIRCRESAHA.119.315529. Epub 2019 Aug 15. Circ Res. 2019. PMID: 31412728 Free PMC article.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Hu T, et al. Among authors: auwerx j. Gastroenterology. 2021 Nov;161(5):1584-1600. doi: 10.1053/j.gastro.2021.06.045. Epub 2021 Jul 8. Gastroenterology. 2021. PMID: 34245764 Free PMC article.
Mitochondrial sirtuins and metabolic homeostasis.
Pirinen E, Lo Sasso G, Auwerx J. Pirinen E, et al. Among authors: auwerx j. Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):759-70. doi: 10.1016/j.beem.2012.05.001. Epub 2012 May 31. Best Pract Res Clin Endocrinol Metab. 2012. PMID: 23168278 Free PMC article. Review.
Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.
Lai L, Yan L, Gao S, Hu CL, Ge H, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx J, Sinclair DA, Vatner SF, Vatner DE. Lai L, et al. Among authors: auwerx j. Circulation. 2013 Apr 23;127(16):1692-701. doi: 10.1161/CIRCULATIONAHA.112.001212. Epub 2013 Mar 27. Circulation. 2013. PMID: 23536361 Free PMC article.
627 results