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Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE).
Sharrack B, Saccardi R, Alexander T, Badoglio M, Burman J, Farge D, Greco R, Jessop H, Kazmi M, Kirgizov K, Labopin M, Mancardi G, Martin R, Moore J, Muraro PA, Rovira M, Sormani MP, Snowden JA; European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE). Sharrack B, et al. Bone Marrow Transplant. 2020 Feb;55(2):283-306. doi: 10.1038/s41409-019-0684-0. Epub 2019 Sep 26. Bone Marrow Transplant. 2020. PMID: 31558790 Free PMC article.
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations fo …
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell …
Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases: overview and future considerations from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Alexander T, Greco R. Alexander T, et al. Bone Marrow Transplant. 2022 Jul;57(7):1055-1062. doi: 10.1038/s41409-022-01702-w. Epub 2022 May 16. Bone Marrow Transplant. 2022. PMID: 35578014 Free PMC article. Review.
Autoimmune diseases (ADs) represent a heterogenous group of complex diseases with increasing incidence in Western countries and are a major cause of morbidity. ...Overall, we discuss past and current indications, efficacy, associated risks and benefits, and f …
Autoimmune diseases (ADs) represent a heterogenous group of complex diseases with increasing incidence in Western count …
New insights in systemic lupus erythematosus: From regulatory T cells to CAR-T-cell strategies.
Doglio M, Alexander T, Del Papa N, Snowden JA, Greco R; Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT). Doglio M, et al. J Allergy Clin Immunol. 2022 Dec;150(6):1289-1301. doi: 10.1016/j.jaci.2022.08.003. Epub 2022 Sep 20. J Allergy Clin Immunol. 2022. PMID: 36137815 Free article. Review.
Systemic lupus erythematous is a heterogeneous autoimmune disease with potentially multiorgan damage. Its complex etiopathogenesis involves genetic, environmental, and hormonal factors, leading to a loss of self-tolerance with autoantibody production and immune complex for …
Systemic lupus erythematous is a heterogeneous autoimmune disease with potentially multiorgan damage. Its complex etiopathogenesis in …
Autologous hematopoietic stem cell transplantation with reduced-intensity conditioning regimens in refractory Takayasu arteritis: a retrospective multicenter case-series from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Laurent C, Marjanovic Z, Ricard L, Henes J, Dulery R, Badoglio M, Farge D, Snowden JA, Moraes D, Dias J, Mohty M, Soussan M, Fain O, Arnold R, Alexander T, Oliveira MC, Mekinian A. Laurent C, et al. Bone Marrow Transplant. 2020 Nov;55(11):2109-2113. doi: 10.1038/s41409-020-0907-4. Epub 2020 Apr 22. Bone Marrow Transplant. 2020. PMID: 32322038
Autologous hematopoietic stem cell transplantation (AHSCT) has emerged as a promising treatment option in severely affected and refractory patients with autoimmune diseases. This is a retrospective survey of patients reported to the EBMT registry betwe …
Autologous hematopoietic stem cell transplantation (AHSCT) has emerged as a promising treatment option in severely affected and refra …
Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Burman J, Kirgizov K, Carlson K, Badoglio M, Mancardi GL, De Luca G, Casanova B, Ouyang J, Bembeeva R, Haas J, Bader P, Snowden J, Farge D. Burman J, et al. Bone Marrow Transplant. 2017 Aug;52(8):1133-1137. doi: 10.1038/bmt.2017.40. Epub 2017 Mar 20. Bone Marrow Transplant. 2017. PMID: 28319075
Autologous hematopoietic stem cell transplantation (aHSCT) is a promising therapy for multiple sclerosis (MS), which has mainly been used in adults. The purpose of this study was to investigate efficacy and adverse events of aHSCT in the treatment of children with MS using …
Autologous hematopoietic stem cell transplantation (aHSCT) is a promising therapy for multiple sclerosis (MS), which has mainly been …
Hematopoietic Stem Cell Transplantation for Autoimmune Disease.
Alexander T, Greco R, Snowden JA. Alexander T, et al. Annu Rev Med. 2021 Jan 27;72:215-228. doi: 10.1146/annurev-med-070119-115617. Epub 2020 Oct 26. Annu Rev Med. 2021. PMID: 33106103 Review.
The introduction of targeted biologic therapies has changed the treatment landscape for autoimmune diseases (ADs) substantially, but although these therapies provide more specificity, they require continuous administration, rarely restore organ function or reverse d …
The introduction of targeted biologic therapies has changed the treatment landscape for autoimmune diseases (ADs) substantiall …
Autoimmune cytopenias (AIC) following allogeneic haematopoietic stem cell transplant for acquired aplastic anaemia: a joint study of the Autoimmune Diseases and Severe Aplastic Anaemia Working Parties (ADWP/SAAWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Miller PDE, Snowden JA, De Latour RP, Iacobelli S, Eikema DJ, Knol C, Marsh JCW, Rice C, Koh M, Fagioli F, Chaganti S, Finke J, Duarte RF, Bader P, Farge D, Passweg JR, Madrigal JA, Dufour C. Miller PDE, et al. Bone Marrow Transplant. 2020 Feb;55(2):441-451. doi: 10.1038/s41409-019-0680-4. Epub 2019 Sep 25. Bone Marrow Transplant. 2020. PMID: 31554929 Free PMC article.
Eight (32%) patients were diagnosed with immune thrombocytopenia (ITP), seven (28%) with autoimmune haemolytic anaemia (AIHA), seven (24%) with Evans syndrome and four (16%) with autoimmune neutropenia (AIN). ...In multivariable Cox analysis of a subgroup of 475 pat …
Eight (32%) patients were diagnosed with immune thrombocytopenia (ITP), seven (28%) with autoimmune haemolytic anaemia (AIHA), seven …
Cardiopulmonary assessment of patients with systemic sclerosis for hematopoietic stem cell transplantation: recommendations from the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party and collaborating partners.
Farge D, Burt RK, Oliveira MC, Mousseaux E, Rovira M, Marjanovic Z, de Vries-Bouwstra J, Del Papa N, Saccardi R, Shah SJ, Lee DC, Denton C, Alexander T, Kiely DG, Snowden JA. Farge D, et al. Bone Marrow Transplant. 2017 Nov;52(11):1495-1503. doi: 10.1038/bmt.2017.56. Epub 2017 May 22. Bone Marrow Transplant. 2017. PMID: 28530671 Free PMC article. Review.
Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar mortality to many cancers. Two randomized controlled trials of autologous hematopoietic stem cell transplantation (AHSCT) for SSc have shown significant improvement in organ function, qua …
Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar mortality to many cancers. Two randomized controlled t …
Haematopoietic stem cell transplantation for severe autoimmune diseases in children: A review of current literature, registry activity and future directions on behalf of the autoimmune diseases and paediatric diseases working parties of the European Society for Blood and Marrow Transplantation.
Achini-Gutzwiller FR, Snowden JA, Corbacioglu S, Greco R; EBMT Autoimmune Diseases (ADWP) and Paediatric Diseases (PDWP) Working Parties. Achini-Gutzwiller FR, et al. Br J Haematol. 2022 Jul;198(1):24-45. doi: 10.1111/bjh.18176. Epub 2022 Apr 27. Br J Haematol. 2022. PMID: 37655707 Review.
Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been used successfully to induce disease control and often apparent cure of severe treatment-refractory autoimmune diseases (ADs) in children. ...This review appraises published li …
Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been used successfully to induce disease control and o …
Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations.
Greco R, Alexander T, Burman J, Del Papa N, de Vries-Bouwstra J, Farge D, Henes J, Kazmi M, Kirgizov K, Muraro PA, Ricart E, Rovira M, Saccardi R, Sharrack B, Snarski E, Withers B, Jessop H, Boglione C, Kramer E, Badoglio M, Labopin M, Orchard K, Corbacioglu S, Ljungman P, Mikulska M, De la Camara R, Snowden JA; European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP), Infectious Diseases Working Party (IDWP), Pediatric Working Party (PWP), Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE), EBMT Nurses Group and Patient Advocacy Committee. Greco R, et al. Bone Marrow Transplant. 2021 Jul;56(7):1493-1508. doi: 10.1038/s41409-021-01326-6. Epub 2021 May 24. Bone Marrow Transplant. 2021. PMID: 34031556 Free PMC article. Review.
Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated …
Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune di …
23 results