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Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage.
Keresteš V, Kubeš J, Applová L, Kollárová P, Lenčová-Popelová O, Melnikova I, Karabanovich G, Khazeem MM, Bavlovič-Piskáčková H, Štěrbová-Kovaříková P, Austin CA, Roh J, Štěrba M, Šimůnek T, Jirkovská A. Keresteš V, et al. Among authors: austin ca. Toxicol Sci. 2024 Mar 26;198(2):288-302. doi: 10.1093/toxsci/kfae008. Toxicol Sci. 2024. PMID: 38290791 Free PMC article.
TOP2B: The First Thirty Years.
Austin CA, Lee KC, Swan RL, Khazeem MM, Manville CM, Cridland P, Treumann A, Porter A, Morris NJ, Cowell IG. Austin CA, et al. Int J Mol Sci. 2018 Sep 14;19(9):2765. doi: 10.3390/ijms19092765. Int J Mol Sci. 2018. PMID: 30223465 Free PMC article. Review.
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions.
Jirkovská A, Karabanovich G, Kubeš J, Skalická V, Melnikova I, Korábečný J, Kučera T, Jirkovský E, Nováková L, Bavlovič Piskáčková H, Škoda J, Štěrba M, Austin CA, Šimůnek T, Roh J. Jirkovská A, et al. Among authors: austin ca. J Med Chem. 2021 Apr 8;64(7):3997-4019. doi: 10.1021/acs.jmedchem.0c02157. Epub 2021 Mar 22. J Med Chem. 2021. PMID: 33750129
TOP2B's contributions to transcription.
Austin CA, Cowell IG, Khazeem MM, Lok D, Ng HT. Austin CA, et al. Biochem Soc Trans. 2021 Dec 17;49(6):2483-2493. doi: 10.1042/BST20200454. Biochem Soc Trans. 2021. PMID: 34747992 Review.
Two type I topoisomerases maintain DNA topology in human mitochondria.
Menger KE, Chapman J, Díaz-Maldonado H, Khazeem MM, Deen D, Erdinc D, Casement JW, Di Leo V, Pyle A, Rodríguez-Luis A, Cowell IG, Falkenberg M, Austin CA, Nicholls TJ. Menger KE, et al. Among authors: austin ca. Nucleic Acids Res. 2022 Oct 28;50(19):11154-11174. doi: 10.1093/nar/gkac857. Nucleic Acids Res. 2022. PMID: 36215039 Free PMC article.
171 results