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Page 1
Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.
Cambon K, Zimmer V, Martineau S, Gaillard MC, Jarrige M, Bugi A, Miniarikova J, Rey M, Hassig R, Dufour N, Auregan G, Hantraye P, Perrier AL, Déglon N. Cambon K, et al. Among authors: auregan g. Mol Ther Methods Clin Dev. 2017 May 11;5:259-276. doi: 10.1016/j.omtm.2017.05.001. eCollection 2017 Jun 16. Mol Ther Methods Clin Dev. 2017. PMID: 28603746 Free PMC article.
The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.
Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E. Galvan L, et al. Among authors: auregan g. Brain. 2018 May 1;141(5):1434-1454. doi: 10.1093/brain/awy057. Brain. 2018. PMID: 29534157 Free PMC article.
The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.
Cresto N, Gaillard MC, Gardier C, Gubinelli F, Diguet E, Bellet D, Legroux L, Mitja J, Auregan G, Guillermier M, Josephine C, Jan C, Dufour N, Joliot A, Hantraye P, Bonvento G, Déglon N, Bemelmans AP, Cambon K, Liot G, Brouillet E. Cresto N, et al. Among authors: auregan g. Neurobiol Dis. 2020 Feb;134:104614. doi: 10.1016/j.nbd.2019.104614. Epub 2019 Oct 9. Neurobiol Dis. 2020. PMID: 31605779 Free article.
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
Cresto N, Gardier C, Gaillard MC, Gubinelli F, Roost P, Molina D, Josephine C, Dufour N, Auregan G, Guillermier M, Bernier S, Jan C, Gipchtein P, Hantraye P, Chartier-Harlin MC, Bonvento G, Van Camp N, Taymans JM, Cambon K, Liot G, Bemelmans AP, Brouillet E. Cresto N, et al. Among authors: auregan g. Int J Mol Sci. 2021 Jun 23;22(13):6760. doi: 10.3390/ijms22136760. Int J Mol Sci. 2021. PMID: 34201785 Free PMC article.
Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.
d'Orange M, Aurégan G, Cheramy D, Gaudin-Guérif M, Lieger S, Guillermier M, Stimmer L, Joséphine C, Hérard AS, Gaillard MC, Petit F, Kiessling MC, Schmitz C, Colin M, Buée L, Panayi F, Diguet E, Brouillet E, Hantraye P, Bemelmans AP, Cambon K. d'Orange M, et al. Among authors: auregan g. Brain. 2018 Feb 1;141(2):535-549. doi: 10.1093/brain/awx342. Brain. 2018. PMID: 29253129 Free PMC article.
Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease.
Ceyzériat K, Ben Haim L, Denizot A, Pommier D, Matos M, Guillemaud O, Palomares MA, Abjean L, Petit F, Gipchtein P, Gaillard MC, Guillermier M, Bernier S, Gaudin M, Aurégan G, Joséphine C, Déchamps N, Veran J, Langlais V, Cambon K, Bemelmans AP, Baijer J, Bonvento G, Dhenain M, Deleuze JF, Oliet SHR, Brouillet E, Hantraye P, Carrillo-de Sauvage MA, Olaso R, Panatier A, Escartin C. Ceyzériat K, et al. Among authors: auregan g. Acta Neuropathol Commun. 2018 Oct 16;6(1):104. doi: 10.1186/s40478-018-0606-1. Acta Neuropathol Commun. 2018. PMID: 30322407 Free PMC article.
Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state.
Maté de Gérando A, d'Orange M, Augustin E, Joséphine C, Aurégan G, Gaudin-Guérif M, Guillermier M, Hérard AS, Stimmer L, Petit F, Gipchtein P, Jan C, Escartin C, Selingue E, Carvalho K, Blum D, Brouillet E, Hantraye P, Gaillard MC, Bonvento G, Bemelmans AP, Cambon K. Maté de Gérando A, et al. Among authors: auregan g. Brain. 2021 May 7;144(4):1167-1182. doi: 10.1093/brain/awab011. Brain. 2021. PMID: 33842937
High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.
Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Aurégan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL. Charbord J, et al. Among authors: auregan g. Stem Cells. 2013 Sep;31(9):1816-28. doi: 10.1002/stem.1430. Stem Cells. 2013. PMID: 23712629
81 results