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Safety, pharmacokinetic, and pharmacodynamic evaluations of PI-2301, a potent immunomodulator, in a first-in-human, single-ascending-dose study in healthy volunteers.
Kovalchin J, Krieger J, Collins K, Genova M, Augustyniak M, Masci A, Avril T, Gandon G, Patat A, Fauchoux N, Toutin C, Lacoste E, Patel U, Mascioli E, Zanelli E. Kovalchin J, et al. Among authors: augustyniak m. J Clin Pharmacol. 2011 May;51(5):649-60. doi: 10.1177/0091270010373930. Epub 2010 Oct 12. J Clin Pharmacol. 2011. PMID: 20940336 Clinical Trial.
Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response.
Kovalchin J, Krieger J, Genova M, Collins K, Augustyniak M, Masci A, Hittinger T, Kuca B, Edan G, Braudeau C, Rimbert M, Patel U, Mascioli E, Zanelli E. Kovalchin J, et al. Among authors: augustyniak m. J Neuroimmunol. 2010 Aug 25;225(1-2):153-63. doi: 10.1016/j.jneuroim.2010.04.008. Epub 2010 May 13. J Neuroimmunol. 2010. PMID: 20466440 Clinical Trial.
NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor.
Ellis JL, Augustyniak ME, Cochran ED, Earl RA, Garvey DS, Gordon LJ, Janero DR, Khanapure SP, Letts LG, Melim TL, Murty MG, Schwalb DJ, Shumway MJ, Selig WM, Trocha AM, Young DV, Zemtseva IS. Ellis JL, et al. Among authors: augustyniak me. Inflammopharmacology. 2005;12(5-6):521-34. doi: 10.1163/156856005774382661. Inflammopharmacology. 2005. PMID: 16259719
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Wey SJ, Augustyniak ME, Cochran ED, Ellis JL, Fang X, Garvey DS, Janero DR, Letts LG, Martino AM, Melim TL, Murty MG, Richardson SK, Schroeder JD, Selig WM, Trocha AM, Wexler RS, Young DV, Zemtseva IS, Zifcak BM. Wey SJ, et al. Among authors: augustyniak me. J Med Chem. 2007 Dec 13;50(25):6367-82. doi: 10.1021/jm0611861. Epub 2007 Nov 10. J Med Chem. 2007. PMID: 17994684
3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation.
Khanapure SP, Augustyniak ME, Earl RA, Garvey DS, Letts LG, Martino AM, Murty MG, Schwalb DJ, Shumway MJ, Trocha AM, Young DV, Zemtseva IS, Janero DR. Khanapure SP, et al. Among authors: augustyniak me. J Med Chem. 2005 Jun 2;48(11):3930-4. doi: 10.1021/jm0582064. J Med Chem. 2005. PMID: 15916445
116 results