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ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.
Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, Lee V, Tan C, Sullivan JP, Larsen JE, Girard L, Behrens C, Wistuba II, Xie Y, Cobb MH, Gazdar AF, Johnson JE, Minna JD. Augustyn A, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14788-93. doi: 10.1073/pnas.1410419111. Epub 2014 Sep 29. Proc Natl Acad Sci U S A. 2014. PMID: 25267614 Free PMC article.
Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.
Shao C, Sullivan JP, Girard L, Augustyn A, Yenerall P, Rodriguez-Canales J, Liu H, Behrens C, Shay JW, Wistuba II, Minna JD. Shao C, et al. Among authors: augustyn a. Clin Cancer Res. 2014 Aug 1;20(15):4154-66. doi: 10.1158/1078-0432.CCR-13-3292. Epub 2014 Jun 6. Clin Cancer Res. 2014. PMID: 24907115 Free PMC article.
Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR. Bunn PA Jr, et al. Among authors: augustyn a. J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. J Thorac Oncol. 2016. PMID: 26829312 Free PMC article. Review. No abstract available.
ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.
Larsen JE, Nathan V, Osborne JK, Farrow RK, Deb D, Sullivan JP, Dospoy PD, Augustyn A, Hight SK, Sato M, Girard L, Behrens C, Wistuba II, Gazdar AF, Hayward NK, Minna JD. Larsen JE, et al. Among authors: augustyn a. J Clin Invest. 2016 Sep 1;126(9):3219-35. doi: 10.1172/JCI76725. Epub 2016 Aug 8. J Clin Invest. 2016. PMID: 27500490 Free PMC article.
Exclusion of patients with brain metastases from cancer clinical trials.
Patel RR, Verma V, Miller AB, Lin TA, Jethanandani A, Espinoza AF, Mainwaring W, Augustyn A, Fuller CD, Sulman EP, Yeboa DN, Chung CC, McAleer MF, Li J, Yoshor D, de Groot JF, Mandel JJ, Ludmir EB. Patel RR, et al. Among authors: augustyn a. Neuro Oncol. 2020 Apr 15;22(4):577-579. doi: 10.1093/neuonc/noz246. Neuro Oncol. 2020. PMID: 31900480 Free PMC article. No abstract available.
39 results