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Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Montoya S, Bourcier J, Noviski M, Lu H, Thompson MC, Chirino A, Jahn J, Sondhi AK, Gajewski S, Tan YSM, Yung S, Urban A, Wang E, Han C, Mi X, Kim WJ, Sievers Q, Auger P, Bousquet H, Brathaban N, Bravo B, Gessner M, Guiducci C, Iuliano JN, Kane T, Mukerji R, Reddy PJ, Powers J, Sanchez Garcia de Los Rios M, Ye J, Barrientos Risso C, Tsai D, Pardo G, Notti RQ, Pardo A, Affer M, Nawaratne V, Totiger TM, Pena-Velasquez C, Rhodes JM, Zelenetz AD, Alencar A, Roeker LE, Mehta S, Garippa R, Linley A, Soni RK, Skånland SS, Brown RJ, Mato AR, Hansen GM, Abdel-Wahab O, Taylor J. Montoya S, et al. Among authors: auger p. Science. 2024 Feb 2;383(6682):eadi5798. doi: 10.1126/science.adi5798. Epub 2024 Feb 2. Science. 2024. PMID: 38301010
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
Robbins DW, Noviski MA, Tan YS, Konst ZA, Kelly A, Auger P, Brathaban N, Cass R, Chan ML, Cherala G, Clifton MC, Gajewski S, Ingallinera TG, Karr D, Kato D, Ma J, McKinnell J, McIntosh J, Mihalic J, Murphy B, Panga JR, Peng G, Powers J, Perez L, Rountree R, Tenn-McClellan A, Sands AT, Weiss DR, Wu J, Ye J, Guiducci C, Hansen G, Cohen F. Robbins DW, et al. Among authors: auger p. J Med Chem. 2024 Feb 22;67(4):2321-2336. doi: 10.1021/acs.jmedchem.3c01007. Epub 2024 Feb 1. J Med Chem. 2024. PMID: 38300987
Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia.
Hsiao-Nakamoto J, Chiu CL, VandeVrede L, Ravi R, Vandenberg B, De Groot J, Tsogtbaatar B, Fang M, Auger P, Gould NS, Marchioni F, Powers CA, Davis SS, Suh JH, Alkabsh J, Heuer HW, Lago AL, Scearce-Levie K, Seeley WW, Boeve BF, Rosen HJ, Berger A, Tsai R, Di Paolo G, Boxer AL, Bhalla A, Huang F; ALLFTD Consortium. Hsiao-Nakamoto J, et al. Among authors: auger p. bioRxiv [Preprint]. 2024 Feb 12:2024.02.09.579529. doi: 10.1101/2024.02.09.579529. bioRxiv. 2024. PMID: 38405775 Free PMC article. Preprint.
Host adaptation and specialization in Tetranychidae mites.
Bruinsma K, Rioja C, Zhurov V, Santamaria ME, Arbona V, Navarro M, Cazaux M, Auger P, Migeon A, Wybouw N, Van Leeuwen T, Diaz I, Gómez-Cadenas A, Grbic M, Navajas M, Grbic V. Bruinsma K, et al. Among authors: auger p. Plant Physiol. 2023 Nov 22;193(4):2605-2621. doi: 10.1093/plphys/kiad412. Plant Physiol. 2023. PMID: 37437113
Herbs carbonization and activation for fast sorption of nitrate ions: a new challenge for a full treatment of groundwater pollution.
Vieillard J, Bouazizi N, Fotsing PN, Samir B, Raguillet K, Cosme J, Serhal CA, Mignot M, Bette MS, Auger P, Dotto GL, Le Derf F. Vieillard J, et al. Among authors: auger p. Environ Sci Pollut Res Int. 2023 Jul;30(34):82637-82646. doi: 10.1007/s11356-023-28282-6. Epub 2023 Jun 17. Environ Sci Pollut Res Int. 2023. PMID: 37328728
Comment on "Pedo-geochemical background and sediment contamination of metal(loid)s in the old mining-district of Salsigne (Orbiel valley, France)" by Gauthier Delplace, Jérôme Viers, Eva Schreck, Priscia Oliva, Philippe Behra published in Chemosphere 287 (2022) 132111.
Melleton J, Belbèze S, Négrel P, Brunet JF, Vic G, Auger P, Chevillard M, Laperche V. Melleton J, et al. Among authors: auger p. Chemosphere. 2022 Nov;307(Pt 2):135768. doi: 10.1016/j.chemosphere.2022.135768. Epub 2022 Jul 21. Chemosphere. 2022. PMID: 35872063 No abstract available.
225 results