Aubé J - Search Results

1

Discovery of sultam-containing small-molecule disruptors of the huntingtin-calmodulin protein-protein interaction.

Klus NJ, Kapadia K, McDonald P, Roy A, Frankowski KJ, Muma NA, Aubé J. Klus NJ, et al. Among authors: aube j. Med Chem Res. 2020 Jul;29(7):1187-1198. doi: 10.1007/s00044-020-02583-8. Epub 2020 Jun 12. Med Chem Res. 2020. PMID: 33642842 Free PMC article.

2

Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence.

Frankowski KJ, Hirt EE, Zeng Y, Neuenswander B, Fowler D, Schoenen F, Aubé J. Frankowski KJ, et al. Among authors: aube j. J Comb Chem. 2007 Nov-Dec;9(6):1188-92. doi: 10.1021/cc700127f. Epub 2007 Sep 27. J Comb Chem. 2007. PMID: 17896822

3

Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Nöth J, Frankowski KJ, Neuenswander B, Aubé J, Reiser O. Nöth J, et al. Among authors: aube j. J Comb Chem. 2008 May-Jun;10(3):456-9. doi: 10.1021/cc700202c. Epub 2008 Mar 14. J Comb Chem. 2008. PMID: 18338857 Free PMC article.

4

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction.

Frankowski KJ, Golden JE, Zeng Y, Lei Y, Aubé J. Frankowski KJ, et al. Among authors: aube j. J Am Chem Soc. 2008 May 7;130(18):6018-24. doi: 10.1021/ja800574m. Epub 2008 Apr 9. J Am Chem Soc. 2008. PMID: 18396881 Free PMC article.

5

Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification.

Frankowski KJ, Neuenswander B, Aubé J. Frankowski KJ, et al. Among authors: aube j. J Comb Chem. 2008 Sep-Oct;10(5):721-5. doi: 10.1021/cc800078h. Epub 2008 Aug 13. J Comb Chem. 2008. PMID: 18698827 Free PMC article.

6

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands.

Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J. Frankowski KJ, et al. Among authors: aube j. ACS Med Chem Lett. 2010 Aug 12;1(5):189-193. doi: 10.1021/ml100040t. ACS Med Chem Lett. 2010. PMID: 20729985 Free PMC article.

7

Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands.

Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Frankowski KJ, et al. Among authors: aube j. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6727-32. doi: 10.1073/pnas.1016558108. Epub 2011 Feb 28. Proc Natl Acad Sci U S A. 2011. PMID: 21368188 Free PMC article.

8

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.

Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN. Li K, et al. Among authors: aube j. J Med Chem. 2012 Apr 12;55(7):3319-30. doi: 10.1021/jm300021v. Epub 2012 Mar 22. J Med Chem. 2012. PMID: 22409723 Free PMC article.

9

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, Heynen-Genel S, Mangravita-Novo A, Vicchiarelli M, Smith LH, Streicher JM, Caron MG, Barak LS, Bohn LM, Chung TD, Aubé J. Frankowski KJ, et al. Among authors: aube j. ACS Chem Neurosci. 2012 Mar 21;3(3):221-236. doi: 10.1021/cn200128x. Epub 2012 Jan 20. ACS Chem Neurosci. 2012. PMID: 22737280 Free PMC article.

10

Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users.

Blake LC, Roy A, Neul D, Schoenen FJ, Aubé J, Scott EE. Blake LC, et al. Among authors: aube j. Pharm Res. 2013 Sep;30(9):2290-302. doi: 10.1007/s11095-013-1054-z. Epub 2013 Jun 12. Pharm Res. 2013. PMID: 23756756 Free PMC article.

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