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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team. Schreiber SL, et al. Among authors: aube j. Cell. 2015 Jun 4;161(6):1252-65. doi: 10.1016/j.cell.2015.05.023. Cell. 2015. PMID: 26046436 Free PMC article. Review.
Facile C-N cleavage in a series of bridged lactams.
Lei Y, Wrobleski AD, Golden JE, Powell DR, Aubé J. Lei Y, et al. Among authors: aube j. J Am Chem Soc. 2005 Apr 6;127(13):4552-3. doi: 10.1021/ja050214m. J Am Chem Soc. 2005. PMID: 15796502
One-step synthesis of oxazoline and dihydrooxazine libraries.
Chaudhry P, Schoenen F, Neuenswander B, Lushington GH, Aubé J. Chaudhry P, et al. Among authors: aube j. J Comb Chem. 2007 May-Jun;9(3):473-6. doi: 10.1021/cc060159t. Epub 2007 Mar 29. J Comb Chem. 2007. PMID: 17391008 Free PMC article.
The NIH's role in accelerating translational sciences.
Reed JC, White EL, Aubé J, Lindsley C, Li M, Sklar L, Schreiber S. Reed JC, et al. Among authors: aube j. Nat Biotechnol. 2012 Jan 9;30(1):16-9. doi: 10.1038/nbt.2087. Nat Biotechnol. 2012. PMID: 22231085 No abstract available.
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, Edwards BS, Peterson BR, Aubé J, Werner-Washburne M, Loewith RJ, De Virgilio C, Sklar LA. Chen J, et al. Among authors: aube j. ACS Chem Biol. 2012 Apr 20;7(4):715-22. doi: 10.1021/cb200452r. Epub 2012 Feb 1. ACS Chem Biol. 2012. PMID: 22260433 Free PMC article.
277 results