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A recombinant chimeric antigen constructed with B-cell epitopes from Mycobacterium leprae hypothetical proteins is effective for the diagnosis of leprosy.
Assis BPN, Chaves AT, Lage DP, Cardoso MM, Pereira IAG, Câmara RSB, Freitas CS, Martins VT, Ludolf F, de Oliveira ALG, Oliveira-da-Silva JA, Tavares GSV, Galdino AS, Chávez-Fumagalli MA, Machado-de-Ávila RA, Christodoulides M, Gonçalves DU, Bueno LL, Fujiwara RT, Coelho EAF, da Costa Rocha MO. Assis BPN, et al. Diagn Microbiol Infect Dis. 2024 May 3;109(3):116338. doi: 10.1016/j.diagmicrobio.2024.116338. Online ahead of print. Diagn Microbiol Infect Dis. 2024. PMID: 38718661
Serodiagnosis of paucibacillary and multibacillary leprosy using a recombinant chimeric protein composed of specific B-cell epitopes derived from Mycobacterium leprae proteins.
Assis BPN, Chaves AT, Lage DP, Cardoso MM, Freitas CS, Pereira IAG, Câmara RSB, Martins VT, de Oliveira ALG, Machado-de-Ávila RA, Galdino AS, Chávez-Fumagalli MA, Christodoulides M, Gonçalves DU, Bueno LL, Fujiwara RT, Coelho EAF, da Costa Rocha MO. Assis BPN, et al. Tuberculosis (Edinb). 2024 Mar 30;147:102505. doi: 10.1016/j.tube.2024.102505. Online ahead of print. Tuberculosis (Edinb). 2024. PMID: 38583359