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Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Ashton TD, Dans MG, Favuzza P, Ngo A, Lehane AM, Zhang X, Qiu D, Chandra Maity B, De N, Schindler KA, Yeo T, Park H, Uhlemann AC, Churchyard A, Baum J, Fidock DA, Jarman KE, Lowes KN, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Ashton TD, et al. J Med Chem. 2023 Mar 9;66(5):3540-3565. doi: 10.1021/acs.jmedchem.2c02092. Epub 2023 Feb 22. J Med Chem. 2023. PMID: 36812492 Free PMC article.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.
Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: ashton td. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30559138 Free PMC article.
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Ashton TD, Ngo A, Favuzza P, Bullen HE, Gancheva MR, Romeo O, Parkyn Schneider M, Nguyen N, Steel RWJ, Duffy S, Lowes KN, Sabroux HJ, Avery VM, Boddey JA, Wilson DW, Cowman AF, Gilson PR, Sleebs BE. Ashton TD, et al. Bioorg Chem. 2021 Dec;117:105359. doi: 10.1016/j.bioorg.2021.105359. Epub 2021 Sep 21. Bioorg Chem. 2021. PMID: 34689083
Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.
Bland ND, Wang C, Tallman C, Gustafson AE, Wang Z, Ashton TD, Ochiana SO, McAllister G, Cotter K, Fang AP, Gechijian L, Garceau N, Gangurde R, Ortenberg R, Ondrechen MJ, Campbell RK, Pollastri MP. Bland ND, et al. Among authors: ashton td. J Med Chem. 2011 Dec 8;54(23):8188-94. doi: 10.1021/jm201148s. Epub 2011 Nov 8. J Med Chem. 2011. PMID: 22023548 Free PMC article.
Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane.
Hickey SM, Ashton TD, Boer G, Bader CA, Thomas M, Elliott AG, Schmuck C, Yu HY, Li J, Nation RL, Cooper MA, Plush SE, Brooks DA, Pfeffer FM. Hickey SM, et al. Among authors: ashton td. Eur J Med Chem. 2018 Dec 5;160:9-22. doi: 10.1016/j.ejmech.2018.09.072. Epub 2018 Oct 3. Eur J Med Chem. 2018. PMID: 30316060 Free PMC article.
Highly fluorescent and HDAC6 selective scriptaid analogues.
Fleming CL, Natoli A, Schreuders J, Devlin M, Yoganantharajah P, Gibert Y, Leslie KG, New EJ, Ashton TD, Pfeffer FM. Fleming CL, et al. Among authors: ashton td. Eur J Med Chem. 2019 Jan 15;162:321-333. doi: 10.1016/j.ejmech.2018.11.020. Epub 2018 Nov 9. Eur J Med Chem. 2019. PMID: 30448419
33 results