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The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.
Botteri G, Salvadó L, Gumà A, Lee Hamilton D, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M. Botteri G, et al. Among authors: ashford mlj. Metabolism. 2018 Aug;85:59-75. doi: 10.1016/j.metabol.2018.03.005. Epub 2018 Mar 9. Metabolism. 2018. PMID: 29526536 Free article.
Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].
Botteri G, Salvadó L, Gumà A, Hamilton DL, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M. Botteri G, et al. Among authors: ashford mlj. Metabolism. 2019 Jul;96:101-102. doi: 10.1016/j.metabol.2019.04.009. Epub 2019 Apr 18. Metabolism. 2019. PMID: 31005247 No abstract available.
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice.
Meakin PJ, Jalicy SM, Montagut G, Allsop DJP, Cavellini DL, Irvine SW, McGinley C, Liddell MK, McNeilly AD, Parmionova K, Liu YR, Bailey CLS, Dale JK, Heisler LK, McCrimmon RJ, Ashford MLJ. Meakin PJ, et al. Among authors: ashford mlj. Sci Rep. 2018 Jan 8;8(1):55. doi: 10.1038/s41598-017-18388-6. Sci Rep. 2018. PMID: 29311632 Free PMC article.
The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
Meakin PJ, Mezzapesa A, Benabou E, Haas ME, Bonardo B, Grino M, Brunel JM, Desbois-Mouthon C, Biddinger SB, Govers R, Ashford MLJ, Peiretti F. Meakin PJ, et al. Among authors: ashford mlj. Nat Commun. 2018 Apr 3;9(1):1306. doi: 10.1038/s41467-018-03755-2. Nat Commun. 2018. PMID: 29610518 Free PMC article.
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.
Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, McCrimmon RJ, Dinkova-Kostova AT, Dillon JF, Hayes JD, Ashford ML. Meakin PJ, et al. Mol Cell Biol. 2014 Sep;34(17):3305-20. doi: 10.1128/MCB.00677-14. Epub 2014 Jun 23. Mol Cell Biol. 2014. PMID: 24958099 Free PMC article.
146 results