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Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
Yeh YT, Sona C, Yan X, Li Y, Pathak A, McDermott MI, Xie Z, Liu L, Arunagiri A, Wang Y, Cazenave-Gassiot A, Ghosh A, von Meyenn F, Kumarasamy S, Najjar SM, Jia S, Wenk MR, Traynor-Kaplan A, Arvan P, Barg S, Bankaitis VA, Poy MN. Yeh YT, et al. Among authors: arvan p. Nat Commun. 2023 Jul 17;14(1):4250. doi: 10.1038/s41467-023-39978-1. Nat Commun. 2023. PMID: 37460527 Free PMC article.
Biosynthesis, structure, and folding of the insulin precursor protein.
Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. Liu M, et al. Among authors: arvan p. Diabetes Obes Metab. 2018 Sep;20 Suppl 2(Suppl 2):28-50. doi: 10.1111/dom.13378. Diabetes Obes Metab. 2018. PMID: 30230185 Free PMC article. Review.
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.
Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT. Ghiasi SM, et al. Among authors: arvan p. Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22. Diabetes. 2019. PMID: 30670477 Free PMC article.
Proinsulin misfolding is an early event in the progression to type 2 diabetes.
Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Arunagiri A, et al. Among authors: arvan p. Elife. 2019 Jun 11;8:e44532. doi: 10.7554/eLife.44532. Elife. 2019. PMID: 31184302 Free PMC article.
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C. Sims EK, et al. Among authors: arvan p. Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9. Transl Res. 2019. PMID: 31442418 Free PMC article.
210 results