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RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine.
Miskelly MG, Lindqvist A, Piccinin E, Hamilton A, Cowan E, Nergård BJ, Del Giudice R, Ngara M, Cataldo LR, Kryvokhyzha D, Volkov P, Engelking L, Artner I, Lagerstedt JO, Eliasson L, Ahlqvist E, Moschetta A, Hedenbro J, Wierup N. Miskelly MG, et al. Among authors: artner i. Diabetologia. 2024 Feb;67(2):356-370. doi: 10.1007/s00125-023-06046-8. Epub 2023 Nov 30. Diabetologia. 2024. PMID: 38032369 Free PMC article.
MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets.
Singh T, Sarmiento L, Luan C, Prasad RB, Johansson J, Cataldo LR, Renström E, Soneji S, Cilio C, Artner I. Singh T, et al. Among authors: artner i. Genes (Basel). 2018 Dec 18;9(12):644. doi: 10.3390/genes9120644. Genes (Basel). 2018. PMID: 30567413 Free PMC article.
Loss of MafA and MafB expression promotes islet inflammation.
Singh T, Colberg JK, Sarmiento L, Chaves P, Hansen L, Bsharat S, Cataldo LR, Dudenhöffer-Pfeifer M, Fex M, Bryder D, Holmberg D, Sitnicka E, Cilio C, Prasad RB, Artner I. Singh T, et al. Among authors: artner i. Sci Rep. 2019 Jun 24;9(1):9074. doi: 10.1038/s41598-019-45528-x. Sci Rep. 2019. PMID: 31235823 Free PMC article.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, Artner I, Suoranta A, Gomez D, Baras A, Champon B, Payne AJ, Moralli D, Thomsen SK, Kramer P, Spiliotis I, Ramracheya R, Chabosseau P, Theodoulou A, Cheung R, van de Bunt M, Flannick J, Trombetta M, Bonora E, Wolheim CB, Sarelin L, Bonadonna RC, Rorsman P, Davies B, Brosnan J, McCarthy MI, Otonkoski T, Lagerstedt JO, Rutter GA, Gromada J, Gloyn AL, Tuomi T, Groop L. Dwivedi OP, et al. Among authors: artner i. Nat Genet. 2019 Nov;51(11):1596-1606. doi: 10.1038/s41588-019-0513-9. Epub 2019 Nov 1. Nat Genet. 2019. PMID: 31676859 Free PMC article.
MAFA and MAFB regulate exocytosis-related genes in human β-cells.
Cataldo LR, Singh T, Achanta K, Bsharat S, Prasad RB, Luan C, Renström E, Eliasson L, Artner I. Cataldo LR, et al. Among authors: artner i. Acta Physiol (Oxf). 2022 Feb;234(2):e13761. doi: 10.1111/apha.13761. Epub 2022 Jan 11. Acta Physiol (Oxf). 2022. PMID: 34978761
Islet Gene View-a tool to facilitate islet research.
Asplund O, Storm P, Chandra V, Hatem G, Ottosson-Laakso E, Mansour-Aly D, Krus U, Ibrahim H, Ahlqvist E, Tuomi T, Renström E, Korsgren O, Wierup N, Ibberson M, Solimena M, Marchetti P, Wollheim C, Artner I, Mulder H, Hansson O, Otonkoski T, Groop L, Prasad RB. Asplund O, et al. Among authors: artner i. Life Sci Alliance. 2022 Aug 10;5(12):e202201376. doi: 10.26508/lsa.202201376. Life Sci Alliance. 2022. PMID: 35948367 Free PMC article.
Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.
Bacos K, Perfilyev A, Karagiannopoulos A, Cowan E, Ofori JK, Bertonnier-Brouty L, Rönn T, Lindqvist A, Luan C, Ruhrmann S, Ngara M, Nilsson Å, Gheibi S, Lyons CL, Lagerstedt JO, Barghouth M, Esguerra JL, Volkov P, Fex M, Mulder H, Wierup N, Krus U, Artner I, Eliasson L, Prasad RB, Cataldo LR, Ling C. Bacos K, et al. Among authors: artner i. J Clin Invest. 2023 Feb 15;133(4):e163612. doi: 10.1172/JCI163612. J Clin Invest. 2023. PMID: 36656641 Free PMC article.
45 results