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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T. Chandra V, et al. Among authors: artner i. Nat Commun. 2022 Oct 26;13(1):6363. doi: 10.1038/s41467-022-34069-z. Nat Commun. 2022. PMID: 36289205 Free PMC article.
MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
Ganic E, Singh T, Luan C, Fadista J, Johansson JK, Cyphert HA, Bennet H, Storm P, Prost G, Ahlenius H, Renström E, Stein R, Groop L, Fex M, Artner I. Ganic E, et al. Among authors: artner i. Cell Rep. 2016 Mar 1;14(8):1991-2002. doi: 10.1016/j.celrep.2016.02.002. Epub 2016 Feb 18. Cell Rep. 2016. PMID: 26904947 Free PMC article.
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH. Axelsson AS, et al. Among authors: artner i. Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652. Nat Commun. 2017. PMID: 28585545 Free PMC article.
Serotonergic regulation of insulin secretion.
Cataldo Bascuñan LR, Lyons C, Bennet H, Artner I, Fex M. Cataldo Bascuñan LR, et al. Among authors: artner i. Acta Physiol (Oxf). 2019 Jan;225(1):e13101. doi: 10.1111/apha.13101. Epub 2018 Jun 20. Acta Physiol (Oxf). 2019. PMID: 29791774 Review.
MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets.
Singh T, Sarmiento L, Luan C, Prasad RB, Johansson J, Cataldo LR, Renström E, Soneji S, Cilio C, Artner I. Singh T, et al. Among authors: artner i. Genes (Basel). 2018 Dec 18;9(12):644. doi: 10.3390/genes9120644. Genes (Basel). 2018. PMID: 30567413 Free PMC article.
Loss of MafA and MafB expression promotes islet inflammation.
Singh T, Colberg JK, Sarmiento L, Chaves P, Hansen L, Bsharat S, Cataldo LR, Dudenhöffer-Pfeifer M, Fex M, Bryder D, Holmberg D, Sitnicka E, Cilio C, Prasad RB, Artner I. Singh T, et al. Among authors: artner i. Sci Rep. 2019 Jun 24;9(1):9074. doi: 10.1038/s41598-019-45528-x. Sci Rep. 2019. PMID: 31235823 Free PMC article.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, Artner I, Suoranta A, Gomez D, Baras A, Champon B, Payne AJ, Moralli D, Thomsen SK, Kramer P, Spiliotis I, Ramracheya R, Chabosseau P, Theodoulou A, Cheung R, van de Bunt M, Flannick J, Trombetta M, Bonora E, Wolheim CB, Sarelin L, Bonadonna RC, Rorsman P, Davies B, Brosnan J, McCarthy MI, Otonkoski T, Lagerstedt JO, Rutter GA, Gromada J, Gloyn AL, Tuomi T, Groop L. Dwivedi OP, et al. Among authors: artner i. Nat Genet. 2019 Nov;51(11):1596-1606. doi: 10.1038/s41588-019-0513-9. Epub 2019 Nov 1. Nat Genet. 2019. PMID: 31676859 Free PMC article.
Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants.
Korchynska S, Krassnitzer M, Malenczyk K, Prasad RB, Tretiakov EO, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger SN, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak DD, Romanov RA, Pifl C, Groop L, Hökfelt TG, Harkany T. Korchynska S, et al. Among authors: artner i. EMBO J. 2020 Jan 2;39(1):e100882. doi: 10.15252/embj.2018100882. Epub 2019 Nov 21. EMBO J. 2020. PMID: 31750562 Free PMC article.
45 results