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Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury.
Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. Ma Z, et al. Among authors: arrojo e drigo r. Gastroenterology. 2022 Feb;162(2):604-620.e20. doi: 10.1053/j.gastro.2021.10.027. Epub 2021 Oct 23. Gastroenterology. 2022. PMID: 34695382 Free PMC article.
Probing β-Cell Biology in Space and Time.
Arrojo E Drigo R. Arrojo E Drigo R. Diabetes. 2021 Oct;70(10):2163-2173. doi: 10.2337/dbi21-0008. Diabetes. 2021. PMID: 34593534 Free PMC article. Review.
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Shrestha S, Erikson G, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Dos Santos C, Shokhirev M, Cartailler JP, Hetzer MW, MacDonald PE, Arrojo E Drigo R. Shrestha S, et al. Among authors: arrojo e drigo r. Sci Adv. 2022 Oct 7;8(40):eabo3932. doi: 10.1126/sciadv.abo3932. Epub 2022 Oct 5. Sci Adv. 2022. PMID: 36197983 Free PMC article.
Age Mosaicism across Multiple Scales in Adult Tissues.
Arrojo E Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer MW. Arrojo E Drigo R, et al. Cell Metab. 2019 Aug 6;30(2):343-351.e3. doi: 10.1016/j.cmet.2019.05.010. Epub 2019 Jun 6. Cell Metab. 2019. PMID: 31178361 Free PMC article.
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Dai XQ, et al. Among authors: arrojo e drigo r. Cell Metab. 2022 Feb 1;34(2):256-268.e5. doi: 10.1016/j.cmet.2021.12.021. Cell Metab. 2022. PMID: 35108513 Free PMC article.
Structural basis for delta cell paracrine regulation in pancreatic islets.
Arrojo E Drigo R, Jacob S, García-Prieto CF, Zheng X, Fukuda M, Nhu HTT, Stelmashenko O, Peçanha FLM, Rodriguez-Diaz R, Bushong E, Deerinck T, Phan S, Ali Y, Leibiger I, Chua M, Boudier T, Song SH, Graf M, Augustine GJ, Ellisman MH, Berggren PO. Arrojo E Drigo R, et al. Nat Commun. 2019 Aug 16;10(1):3700. doi: 10.1038/s41467-019-11517-x. Nat Commun. 2019. PMID: 31420552 Free PMC article.
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