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Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants.
Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW, Lillo AM, Sundaram S, Bloom J, Diamond MS, Crowe JE Jr, Carnahan RH, Faissol DM. Desautels TA, et al. Among authors: arrildt kt. bioRxiv [Preprint]. 2023 Apr 24:2022.10.21.513237. doi: 10.1101/2022.10.21.513237. bioRxiv. 2023. PMID: 36324800 Free PMC article. Preprint.
Multiple Mutations Associated with Emergent Variants Can Be Detected as Low-Frequency Mutations in Early SARS-CoV-2 Pandemic Clinical Samples.
Kimbrel J, Moon J, Avila-Herrera A, Martí JM, Thissen J, Mulakken N, Sandholtz SH, Ferrell T, Daum C, Hall S, Segelke B, Arrildt KT, Messenger S, Wadford DA, Jaing C, Allen JE, Borucki MK. Kimbrel J, et al. Among authors: arrildt kt. Viruses. 2022 Dec 13;14(12):2775. doi: 10.3390/v14122775. Viruses. 2022. PMID: 36560780 Free PMC article.
Computationally restoring the potency of a clinical antibody against Omicron.
Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW; Tri-lab COVID-19 Consortium; Lillo AM, Sundaram S, Bloom JD, Diamond MS, Crowe JE Jr, Carnahan RH, Faissol DM. Desautels TA, et al. Among authors: arrildt kt. Nature. 2024 May 8. doi: 10.1038/s41586-024-07385-1. Online ahead of print. Nature. 2024. PMID: 38720086
A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.
Maruggi G, Mallett CP, Westerbeck JW, Chen T, Lofano G, Friedrich K, Qu L, Sun JT, McAuliffe J, Kanitkar A, Arrildt KT, Wang KF, McBee I, McCoy D, Terry R, Rowles A, Abrahim MA, Ringenberg MA, Gains MJ, Spickler C, Xie X, Zou J, Shi PY, Dutt T, Henao-Tamayo M, Ragan I, Bowen RA, Johnson R, Nuti S, Luisi K, Ulmer JB, Steff AM, Jalah R, Bertholet S, Stokes AH, Yu D. Maruggi G, et al. Among authors: arrildt kt. Mol Ther. 2022 May 4;30(5):1897-1912. doi: 10.1016/j.ymthe.2022.01.001. Epub 2022 Jan 3. Mol Ther. 2022. PMID: 34990810 Free PMC article. Clinical Trial.
Phenotypic Correlates of HIV-1 Macrophage Tropism.
Arrildt KT, LaBranche CC, Joseph SB, Dukhovlinova EN, Graham WD, Ping LH, Schnell G, Sturdevant CB, Kincer LP, Mallewa M, Heyderman RS, Rie AV, Cohen MS, Spudich S, Price RW, Montefiori DC, Swanstrom R. Arrildt KT, et al. J Virol. 2015 Nov;89(22):11294-311. doi: 10.1128/JVI.00946-15. Epub 2015 Sep 2. J Virol. 2015. PMID: 26339058 Free PMC article.
R5 Macrophage-Tropic HIV-1 in the Male Genital Tract.
Bednar MM, Hauser BM, Ping LH, Dukhovlinova E, Zhou S, Arrildt KT, Hoffman IF, Eron JJ, Cohen MS, Swanstrom R. Bednar MM, et al. Among authors: arrildt kt. J Virol. 2015 Oct;89(20):10688-92. doi: 10.1128/JVI.01842-15. Epub 2015 Jul 29. J Virol. 2015. PMID: 26223642 Free PMC article.
Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS.
Bednar MM, Sturdevant CB, Tompkins LA, Arrildt KT, Dukhovlinova E, Kincer LP, Swanstrom R. Bednar MM, et al. Among authors: arrildt kt. Curr HIV/AIDS Rep. 2015 Jun;12(2):262-71. doi: 10.1007/s11904-015-0265-9. Curr HIV/AIDS Rep. 2015. PMID: 25914150 Free PMC article. Review.
HIV-1 target cells in the CNS.
Joseph SB, Arrildt KT, Sturdevant CB, Swanstrom R. Joseph SB, et al. Among authors: arrildt kt. J Neurovirol. 2015 Jun;21(3):276-89. doi: 10.1007/s13365-014-0287-x. Epub 2014 Sep 19. J Neurovirol. 2015. PMID: 25236812 Free PMC article. Review.
12 results