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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Nat Cancer. 2023 Jun;4(6):812-828. doi: 10.1038/s43018-023-00577-0. Epub 2023 Jun 5.
Nat Cancer. 2023.
PMID: 37277530
Free PMC article.
T cell-dependent bispecific antibodies alter organ-specific endothelial cell-T cell interaction.
Himmels P, Nguyen TTT, Mitzner MC, Arrazate A, Yeung S, Burton J, Clark R, Totpal K, Jesudason R, Yang A, Solon M, Eastham J, Modrusan Z, Webster JD, Lo AA, Piskol R, Ye W.
Himmels P, et al. Among authors: arrazate a.
EMBO Rep. 2023 Mar 6;24(3):e55532. doi: 10.15252/embr.202255532. Epub 2023 Jan 9.
EMBO Rep. 2023.
PMID: 36621885
Free PMC article.
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Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
Taylor AM, Williams BR, Giordanetto F, Kelley EH, Lescarbeau A, Shortsleeves K, Tang Y, Walters WP, Arrazate A, Bowman C, Brophy E, Chan EW, Deshmukh G, Greisman JB, Hunsaker TL, Kipp DR, Saenz Lopez-Larrocha P, Maddalo D, Martin IJ, Maragakis P, Merchant M, Murcko M, Nisonoff H, Nguyen V, Nguyen V, Orozco O, Owen C, Pierce L, Schmidt M, Shaw DE, Smith S, Therrien E, Tran JC, Watters J, Waters NJ, Wilbur J, Willmore L.
Taylor AM, et al. Among authors: arrazate a.
J Med Chem. 2023 Oct 12;66(19):13384-13399. doi: 10.1021/acs.jmedchem.3c00483. Epub 2023 Sep 29.
J Med Chem. 2023.
PMID: 37774359
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IFNγ-induced Chemokines Are Required for CXCR3-mediated T-Cell Recruitment and Antitumor Efficacy of Anti-HER2/CD3 Bispecific Antibody.
Li J, Ybarra R, Mak J, Herault A, De Almeida P, Arrazate A, Ziai J, Totpal K, Junttila MR, Walsh KB, Junttila TT.
Li J, et al. Among authors: arrazate a.
Clin Cancer Res. 2018 Dec 15;24(24):6447-6458. doi: 10.1158/1078-0432.CCR-18-1139. Epub 2018 Jun 27.
Clin Cancer Res. 2018.
PMID: 29950350
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The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.
Joseph JD, et al. Among authors: arrazate a.
Elife. 2016 Jul 13;5:e15828. doi: 10.7554/eLife.15828.
Elife. 2016.
PMID: 27410477
Free PMC article.
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Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity.
Chiang PC, Gould S, Nannini M, Qin A, Deng Y, Arrazate A, Kam KR, Ran Y, Wong H.
Chiang PC, et al. Among authors: arrazate a.
Nanoscale Res Lett. 2014 Apr 1;9(1):156. doi: 10.1186/1556-276X-9-156.
Nanoscale Res Lett. 2014.
PMID: 24685243
Free PMC article.
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Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.
Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.
Joseph JD, et al. Among authors: arrazate a.
Elife. 2019 Jan 7;8:e44851. doi: 10.7554/eLife.44851.
Elife. 2019.
PMID: 30614786
Free PMC article.
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