Arora S - Search Results

1

Mechanistic modeling of drug products applied to the skin: A workshop summary report.

Tsakalozou E, Alam K, Ghosh P, Spires J, Polak S, Fang L, Sammeta S, Zhao P, Arora S, Raney SG. Tsakalozou E, et al. Among authors: arora s. CPT Pharmacometrics Syst Pharmacol. 2023 May;12(5):575-584. doi: 10.1002/psp4.12893. Epub 2022 Dec 1. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 36456539 Free PMC article. Review.

2

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations.

Puttrevu SK, Arora S, Polak S, Patel NK. Puttrevu SK, et al. Among authors: arora s. Pharmaceutics. 2020 Sep 30;12(10):942. doi: 10.3390/pharmaceutics12100942. Pharmaceutics. 2020. PMID: 33008144 Free PMC article.

3

Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin.

Patel N, Clarke JF, Salem F, Abdulla T, Martins F, Arora S, Tsakalozou E, Hodgkinson A, Arjmandi-Tash O, Cristea S, Ghosh P, Alam K, Raney SG, Jamei M, Polak S. Patel N, et al. Among authors: arora s. CPT Pharmacometrics Syst Pharmacol. 2022 Aug;11(8):1060-1084. doi: 10.1002/psp4.12814. Epub 2022 Jun 27. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35670226 Free PMC article.

4

Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model.

Arora S, Clarke J, Tsakalozou E, Ghosh P, Alam K, Grice JE, Roberts MS, Jamei M, Polak S. Arora S, et al. Mol Pharm. 2022 Sep 5;19(9):3139-3152. doi: 10.1021/acs.molpharmaceut.2c00229. Epub 2022 Aug 15. Mol Pharm. 2022. PMID: 35969125

5

Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application.

Thakur K, Telaprolu KC, Paterson D, Salem F, Arora S, Polak S. Thakur K, et al. Among authors: arora s. Br J Clin Pharmacol. 2024 Mar 7. doi: 10.1111/bcp.16029. Online ahead of print. Br J Clin Pharmacol. 2024. PMID: 38450818

6

Physiologically Based Biopharmaceutics Modeling (PBBM): Best Practices for Drug Product Quality, Regulatory and Industry Perspectives: 2023 Workshop Summary Report.

Mackie C, Arora S, Seo P, Moody R, Rege B, Pepin X, Heimbach T, Tannergren C, Mitra A, Suarez-Sharp S, Borges LN, Kijima S, Kotzagiorgis E, Malamatari M, Veerasingham S, Polli JE, Rullo G. Mackie C, et al. Among authors: arora s. Mol Pharm. 2024 May 6;21(5):2065-2080. doi: 10.1021/acs.molpharmaceut.4c00202. Epub 2024 Apr 10. Mol Pharm. 2024. PMID: 38600804 Free PMC article. Review.

7

A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates.

Arora S, Pansari A, Kilford PJ, Jamei M, Turner DB, Gardner I. Arora S, et al. Eur J Drug Metab Pharmacokinet. 2022 Jul;47(4):483-495. doi: 10.1007/s13318-022-00765-w. Epub 2022 Apr 29. Eur J Drug Metab Pharmacokinet. 2022. PMID: 35486324

8

Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions.

Arora S, Pansari A, Kilford P, Jamei M, Gardner I, Turner DB. Arora S, et al. Mol Pharm. 2020 Jul 6;17(7):2329-2344. doi: 10.1021/acs.molpharmaceut.0c00043. Epub 2020 Jun 1. Mol Pharm. 2020. PMID: 32427480

9

Evaluating the impact of acid-reducing agents on drug absorption using biorelevant in vitro tools and PBPK modeling - case example dipyridamole.

Segregur D, Barker R, Mann J, Moir A, Karlsson EM, Turner DB, Arora S, Dressman J. Segregur D, et al. Among authors: arora s. Eur J Pharm Sci. 2021 May 1;160:105750. doi: 10.1016/j.ejps.2021.105750. Epub 2021 Feb 11. Eur J Pharm Sci. 2021. PMID: 33581261

10

Biorelevant Two-Stage In Vitro Testing for rDCS Classification and in PBPK Modeling-Case Example Ritonavir.

Fiolka T, Van Den Abeele J, Augustijns P, Arora S, Dressman J. Fiolka T, et al. Among authors: arora s. J Pharm Sci. 2020 Aug;109(8):2512-2526. doi: 10.1016/j.xphs.2020.04.023. Epub 2020 May 7. J Pharm Sci. 2020. PMID: 32387425

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