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Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.
Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM. Poe MM, et al. Among authors: arnold la. J Med Chem. 2016 Dec 8;59(23):10800-10806. doi: 10.1021/acs.jmedchem.6b01332. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933953 Free PMC article.
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.
Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. Nandhikonda P, et al. Among authors: arnold la. Biochemistry. 2013 Jun 18;52(24):4193-203. doi: 10.1021/bi400321p. Epub 2013 Jun 10. Biochemistry. 2013. PMID: 23713684 Free PMC article.
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Sidhu PS, et al. Among authors: arnold la. ACS Med Chem Lett. 2014 Feb 13;5(2):199-204. doi: 10.1021/ml400462j. ACS Med Chem Lett. 2014. PMID: 24799995 Free PMC article.
Anticancer activity of VDR-coregulator inhibitor PS121912.
Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Sidhu PS, et al. Among authors: arnold la. Cancer Chemother Pharmacol. 2014 Oct;74(4):787-98. doi: 10.1007/s00280-014-2549-y. Epub 2014 Aug 9. Cancer Chemother Pharmacol. 2014. PMID: 25107568 Free PMC article.
Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. Guthrie ML, et al. Among authors: arnold la. Anticancer Res. 2015 Nov;35(11):6001-7. Anticancer Res. 2015. PMID: 26504023 Free PMC article.
113 results