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A decade of experience with genetically tailored pig models for diabetes and metabolic research.
Zettler S, Renner S, Kemter E, Hinrichs A, Klymiuk N, Backman M, Riedel EO, Mueller C, Streckel E, Braun-Reichhart C, Martins AS, Kurome M, Keßler B, Zakhartchenko V, Flenkenthaler F, Arnold GJ, Fröhlich T, Blum H, Blutke A, Wanke R, Wolf E. Zettler S, et al. Among authors: arnold gj. Anim Reprod. 2020 Aug 26;17(3):e20200064. doi: 10.1590/1984-3143-AR2020-0064. Anim Reprod. 2020. PMID: 33029223 Free PMC article. Review.
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
Hinrichs A, Riedel EO, Klymiuk N, Blutke A, Kemter E, Längin M, Dahlhoff M, Keßler B, Kurome M, Zakhartchenko V, Jemiller EM, Ayares D, Bidlingmaier M, Flenkenthaler F, Hrabĕ de Angelis M, Arnold GJ, Reichart B, Fröhlich T, Wolf E. Hinrichs A, et al. Among authors: arnold gj. Xenotransplantation. 2021 Mar;28(2):e12664. doi: 10.1111/xen.12664. Epub 2020 Nov 25. Xenotransplantation. 2021. PMID: 33241624
The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E. Blutke A, et al. Among authors: arnold gj. Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug. Mol Metab. 2017. PMID: 28752056 Free PMC article.
Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.
Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fröhlich T, Wolf E. Riedel EO, et al. Among authors: arnold gj. Mol Metab. 2020 Jun;36:100978. doi: 10.1016/j.molmet.2020.100978. Epub 2020 Mar 18. Mol Metab. 2020. PMID: 32277923 Free PMC article.
A scalable, clinically severe pig model for Duchenne muscular dystrophy.
Stirm M, Fonteyne LM, Shashikadze B, Lindner M, Chirivi M, Lange A, Kaufhold C, Mayer C, Medugorac I, Kessler B, Kurome M, Zakhartchenko V, Hinrichs A, Kemter E, Krause S, Wanke R, Arnold GJ, Wess G, Nagashima H, Hrabĕ de Angelis M, Flenkenthaler F, Kobelke LA, Bearzi C, Rizzi R, Bähr A, Reese S, Matiasek K, Walter MC, Kupatt C, Ziegler S, Bartenstein P, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Stirm M, et al. Among authors: arnold gj. Dis Model Mech. 2021 Dec 1;14(12):dmm049285. doi: 10.1242/dmm.049285. Epub 2021 Dec 16. Dis Model Mech. 2021. PMID: 34796900 Free PMC article.
Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue-Multi-omics Insights From the Munich MIDY Pig Model.
Flenkenthaler F, Ländström E, Shashikadze B, Backman M, Blutke A, Philippou-Massier J, Renner S, Hrabe de Angelis M, Wanke R, Blum H, Arnold GJ, Wolf E, Fröhlich T. Flenkenthaler F, et al. Among authors: arnold gj. Front Med (Lausanne). 2021 Nov 23;8:751277. doi: 10.3389/fmed.2021.751277. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34888323 Free PMC article.
Pig models for Duchenne muscular dystrophy - from disease mechanisms to validation of new diagnostic and therapeutic concepts.
Stirm M, Fonteyne LM, Shashikadze B, Stöckl JB, Kurome M, Keßler B, Zakhartchenko V, Kemter E, Blum H, Arnold GJ, Matiasek K, Wanke R, Wurst W, Nagashima H, Knieling F, Walter MC, Kupatt C, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Stirm M, et al. Among authors: arnold gj. Neuromuscul Disord. 2022 Jul;32(7):543-556. doi: 10.1016/j.nmd.2022.04.005. Epub 2022 Apr 25. Neuromuscul Disord. 2022. PMID: 35659494 Free article. Review.
136 results