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Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity.
Alcázar Magaña A, Vaswani A, Brown KS, Jiang Y, Alam MN, Caruso M, Lak P, Cheong P, Gray NE, Quinn JF, Soumyanath A, Stevens JF, Maier CS. Alcázar Magaña A, et al. Molecules. 2024 Feb 13;29(4):838. doi: 10.3390/molecules29040838. Molecules. 2024. PMID: 38398590 Free PMC article.
Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.
Gray NE, Hack W, Brandes MS, Zweig JA, Yang L, Marney L, Choi J, Magana AA, Cerruti N, McFerrin J, Koike S, Nguyen T, Raber J, Quinn JF, Maier CS, Soumyanath A. Gray NE, et al. Among authors: magana aa. bioRxiv [Preprint]. 2024 Jan 24:2024.01.23.576700. doi: 10.1101/2024.01.23.576700. bioRxiv. 2024. PMID: 38328129 Free PMC article. Preprint.
Quantification of Caffeoylquinic Acids and Triterpenes as Targeted Bioactive Compounds of Centella asiatica in Extracts and Formulations by Liquid Chromatography Mass Spectrometry.
Yang L, Marney L, Magana AA, Choi J, Wright K, Mcferrin J, Gray NE, Soumyanath A, Stevens JF, Maier CS. Yang L, et al. Among authors: magana aa. J Chromatogr Open. 2023 Nov 27;4:100091. doi: 10.1016/j.jcoa.2023.100091. Epub 2023 Jul 8. J Chromatogr Open. 2023. PMID: 37789901 Free PMC article.
Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults.
Wright KM, Bollen M, David J, Mepham B, Alcázar Magaña A, McClure C, Maier CS, Quinn JF, Soumyanath A. Wright KM, et al. Among authors: alcazar magana a. Front Pharmacol. 2023 Aug 23;14:1228030. doi: 10.3389/fphar.2023.1228030. eCollection 2023. Front Pharmacol. 2023. PMID: 37680716 Free PMC article.
Computation-Assisted Identification of Bioactive Compounds in Botanical Extracts: A Case Study of Anti-Inflammatory Natural Products from Hops.
Brown KS, Jamieson P, Wu W, Vaswani A, Alcazar Magana A, Choi J, Mattio LM, Cheong PH, Nelson D, Reardon PN, Miranda CL, Maier CS, Stevens JF. Brown KS, et al. Among authors: alcazar magana a. Antioxidants (Basel). 2022 Jul 19;11(7):1400. doi: 10.3390/antiox11071400. Antioxidants (Basel). 2022. PMID: 35883889 Free PMC article.
Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial.
Wright KM, Bollen M, David J, Speers AB, Brandes MS, Gray NE, Alcázar Magaña A, McClure C, Stevens JF, Maier CS, Quinn JF, Soumyanath A. Wright KM, et al. Among authors: alcazar magana a. Antioxidants (Basel). 2022 Jan 23;11(2):215. doi: 10.3390/antiox11020215. Antioxidants (Basel). 2022. PMID: 35204098 Free PMC article.
31 results