Arlt VM - Search Results

1

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.

Indra R, Pompach P, Martínek V, Takácsová P, Vavrová K, Heger Z, Adam V, Eckschlager T, Kopečková K, Arlt VM, Stiborová M. Indra R, et al. Among authors: arlt vm. Int J Mol Sci. 2019 Jul 10;20(14):3392. doi: 10.3390/ijms20143392. Int J Mol Sci. 2019. PMID: 31295928 Free PMC article.

2

Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.

Arlt VM, Stiborova M, Schmeiser HH. Arlt VM, et al. Mutagenesis. 2002 Jul;17(4):265-77. doi: 10.1093/mutage/17.4.265. Mutagenesis. 2002. PMID: 12110620 Review.

3

Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes.

Frei E, Bieler CA, Arlt VM, Wiessler M, Stiborová M. Frei E, et al. Among authors: arlt vm. Biochem Pharmacol. 2002 Jul 15;64(2):289-95. doi: 10.1016/s0006-2952(02)01072-9. Biochem Pharmacol. 2002. PMID: 12123750

4

Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.

Arlt VM, Stiborova M, Hewer A, Schmeiser HH, Phillips DH. Arlt VM, et al. Cancer Res. 2003 Jun 1;63(11):2752-61. Cancer Res. 2003. PMID: 12782579

5

3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

Arlt VM, Hewer A, Sorg BL, Schmeiser HH, Phillips DH, Stiborova M. Arlt VM, et al. Chem Res Toxicol. 2004 Aug;17(8):1092-101. doi: 10.1021/tx049912v. Chem Res Toxicol. 2004. PMID: 15310241

6

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

Arlt VM, Stiborova M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martinek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH. Arlt VM, et al. Cancer Res. 2005 Apr 1;65(7):2644-52. doi: 10.1158/0008-5472.CAN-04-3544. Cancer Res. 2005. PMID: 15805261

7

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.

Arlt VM, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Stiborova M. Arlt VM, et al. Cancer Lett. 2006 Mar 28;234(2):220-31. doi: 10.1016/j.canlet.2005.03.035. Cancer Lett. 2006. PMID: 15885895

8

Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.

Stiborová M, Arlt VM, Henderson CJ, Wolf CR, Frei E, Schmeiser HH, Phillips DH. Stiborová M, et al. Among authors: arlt vm. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):191-7. doi: 10.5507/bp.2005.025. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601755 Review.

9

The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.

Stiborová M, Dracínská H, Hájková J, Kaderábková P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: arlt vm. Drug Metab Dispos. 2006 Aug;34(8):1398-405. doi: 10.1124/dmd.106.009373. Epub 2006 May 19. Drug Metab Dispos. 2006. PMID: 16714372

10

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

Stiborová M, Frei E, Arlt VM, Schmeiser HH. Stiborová M, et al. Among authors: arlt vm. Mutat Res. 2008 Jan-Feb;658(1-2):55-67. doi: 10.1016/j.mrrev.2007.07.003. Epub 2007 Aug 6. Mutat Res. 2008. PMID: 17851120 Free article. Review.

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