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Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.
Lutchman V, Medkour Y, Samson E, Arlia-Ciommo A, Dakik P, Cortes B, Feldman R, Mohtashami S, McAuley M, Chancharoen M, Rukundo B, Simard É, Titorenko VI. Lutchman V, et al. Among authors: arlia ciommo a. Oncotarget. 2016 Mar 29;7(13):16542-66. doi: 10.18632/oncotarget.7665. Oncotarget. 2016. PMID: 26918729 Free PMC article.
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.
Leonov A, Arlia-Ciommo A, Bourque SD, Koupaki O, Kyryakov P, Dakik P, McAuley M, Medkour Y, Mohammad K, Di Maulo T, Titorenko VI. Leonov A, et al. Among authors: arlia ciommo a. Oncotarget. 2017 May 9;8(19):30672-30691. doi: 10.18632/oncotarget.16766. Oncotarget. 2017. PMID: 28410198 Free PMC article.
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.
Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI. Leonov A, et al. Among authors: arlia ciommo a. Oncotarget. 2017 Sep 1;8(41):69328-69350. doi: 10.18632/oncotarget.20614. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050207 Free PMC article.
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.
Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI. Arlia-Ciommo A, et al. Oncotarget. 2018 Mar 5;9(22):16163-16184. doi: 10.18632/oncotarget.24604. eCollection 2018 Mar 23. Oncotarget. 2018. PMID: 29662634 Free PMC article.
Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.
Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI. Medkour Y, et al. Among authors: arlia ciommo a. Oncotarget. 2019 Oct 8;10(56):5780-5816. doi: 10.18632/oncotarget.27209. eCollection 2019 Oct 8. Oncotarget. 2019. PMID: 31645900 Free PMC article.
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