Arkin MR - Search Results

1

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation.

Jiang Z, Kuo YH, Arkin MR. Jiang Z, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Nov 8;145(44):23939-23947. doi: 10.1021/jacs.3c05199. Epub 2023 Sep 25. J Am Chem Soc. 2023. PMID: 37748140 Free PMC article.

2

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions.

Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR. Jiang Z, et al. Among authors: arkin mr. J Am Chem Soc. 2022 Jul 27;144(29):13218-13225. doi: 10.1021/jacs.2c03665. Epub 2022 Jul 12. J Am Chem Soc. 2022. PMID: 35819848 Free PMC article.

3

LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface.

Tang Y, Kay A, Jiang Z, Arkin MR. Tang Y, et al. Among authors: arkin mr. Biochemistry. 2022 Nov 1;61(21):2295-2302. doi: 10.1021/acs.biochem.2c00482. Epub 2022 Oct 20. Biochemistry. 2022. PMID: 36264309 Free PMC article.

4

Synthetic autophagy receptor.

Jiang Z, Kuo YH, Arkin MR. Jiang Z, et al. Among authors: arkin mr. Autophagy. 2024 Mar;20(3):701-703. doi: 10.1080/15548627.2023.2278954. Epub 2024 Feb 14. Autophagy. 2024. PMID: 37934826

5

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.

Somsen BA, Schellekens RJC, Verhoef CJA, Arkin MR, Ottmann C, Cossar PJ, Brunsveld L. Somsen BA, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Mar 29;145(12):6741-6752. doi: 10.1021/jacs.2c12781. Epub 2023 Mar 16. J Am Chem Soc. 2023. PMID: 36926879 Free PMC article.

6

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.

Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. Van Horn KS, et al. Among authors: arkin mr. J Am Chem Soc. 2023 May 10;145(18):10015-10021. doi: 10.1021/jacs.2c12240. Epub 2023 Apr 27. J Am Chem Soc. 2023. PMID: 37104712 Free PMC article.

7

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.

Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR. Konstantinidou M, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343. doi: 10.1021/jacs.3c05161. Epub 2023 Sep 7. J Am Chem Soc. 2023. PMID: 37676236 Free PMC article.

8

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.

Sijbesma E, Hallenbeck KK, Leysen S, de Vink PJ, Skóra L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C. Sijbesma E, et al. Among authors: arkin mr. J Am Chem Soc. 2019 Feb 27;141(8):3524-3531. doi: 10.1021/jacs.8b11658. Epub 2019 Feb 19. J Am Chem Soc. 2019. PMID: 30707565

9

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.

Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. Braisted AC, et al. Among authors: arkin mr. J Am Chem Soc. 2003 Apr 2;125(13):3714-5. doi: 10.1021/ja034247i. J Am Chem Soc. 2003. PMID: 12656598

10

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.

Chin MY, Ang KH, Davies J, Alquezar C, Garda VG, Rooney B, Leng K, Kampmann M, Arkin MR, Kao AW. Chin MY, et al. Among authors: arkin mr. ACS Chem Neurosci. 2022 May 18;13(10):1505-1516. doi: 10.1021/acschemneuro.1c00804. Epub 2022 May 6. ACS Chem Neurosci. 2022. PMID: 35522480 Free PMC article.

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