Arkin MR - Search Results

1

Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions.

Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR. Pfaff SJ, et al. Among authors: arkin mr. Methods Mol Biol. 2015;1278:587-613. doi: 10.1007/978-1-4939-2425-7_39. Methods Mol Biol. 2015. PMID: 25859978

2

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. Raimundo BC, et al. Among authors: arkin mr. J Med Chem. 2004 Jun 3;47(12):3111-30. doi: 10.1021/jm049967u. J Med Chem. 2004. PMID: 15163192

3

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.

Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr. Bagriantsev SN, et al. Among authors: arkin mr. ACS Chem Biol. 2013 Aug 16;8(8):1841-51. doi: 10.1021/cb400289x. Epub 2013 Jun 17. ACS Chem Biol. 2013. PMID: 23738709 Free PMC article.

4

Tailoring small molecules for an allosteric site on procaspase-6.

Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Murray J, et al. Among authors: arkin mr. ChemMedChem. 2014 Jan;9(1):73-7, 2. doi: 10.1002/cmdc.201300424. Epub 2013 Nov 20. ChemMedChem. 2014. PMID: 24259468

5

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Chou TF, et al. Among authors: arkin mr. J Mol Biol. 2014 Jul 29;426(15):2886-99. doi: 10.1016/j.jmb.2014.05.022. Epub 2014 May 27. J Mol Biol. 2014. PMID: 24878061 Free PMC article.

6

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

Arkin MR, Tang Y, Wells JA. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. doi: 10.1016/j.chembiol.2014.09.001. Chem Biol. 2014. PMID: 25237857 Free PMC article. Review.

7

Lead identification to clinical candidate selection: drugs for Chagas disease.

Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Neitz RJ, et al. J Biomol Screen. 2015 Jan;20(1):101-11. doi: 10.1177/1087057114553103. Epub 2014 Oct 3. J Biomol Screen. 2015. PMID: 25281737

8

A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.

Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. Chimenti MS, et al. Among authors: arkin mr. J Biomol Screen. 2015 Jul;20(6):788-800. doi: 10.1177/1087057115570550. Epub 2015 Feb 17. J Biomol Screen. 2015. PMID: 25690569

9

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM. Alverez C, et al. Among authors: arkin mr. ACS Med Chem Lett. 2015 Dec 22;7(2):182-7. doi: 10.1021/acsmedchemlett.5b00396. eCollection 2016 Feb 11. ACS Med Chem Lett. 2015. PMID: 26985295 Free PMC article.

10

A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments.

Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR. Hallenbeck KK, et al. Among authors: arkin mr. SLAS Discov. 2018 Feb;23(2):183-192. doi: 10.1177/2472555217732072. Epub 2017 Sep 25. SLAS Discov. 2018. PMID: 28945980 Free PMC article.

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