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The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.
Doré E, Joly-Beauparlant C, Morozumi S, Mathieu A, Lévesque T, Allaeys I, Duchez AC, Cloutier N, Leclercq M, Bodein A, Payré C, Martin C, Petit-Paitel A, Gelb MH, Rangachari M, Murakami M, Davidovic L, Flamand N, Arita M, Lambeau G, Droit A, Boilard E. Doré E, et al. Among authors: arita m. JCI Insight. 2022 Jan 25;7(2):e152638. doi: 10.1172/jci.insight.152638. JCI Insight. 2022. PMID: 35076027 Free PMC article.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M. Taketomi Y, et al. Among authors: arita m. Nat Immunol. 2013 Jun;14(6):554-63. doi: 10.1038/ni.2586. Epub 2013 Apr 28. Nat Immunol. 2013. PMID: 23624557 Free PMC article.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M. Miki Y, et al. Among authors: arita m. J Exp Med. 2013 Jun 3;210(6):1217-34. doi: 10.1084/jem.20121887. Epub 2013 May 20. J Exp Med. 2013. PMID: 23690440 Free PMC article.
Structures and functions of the gut microbial lipidome.
Morozumi S, Ueda M, Okahashi N, Arita M. Morozumi S, et al. Among authors: arita m. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159110. doi: 10.1016/j.bbalip.2021.159110. Epub 2022 Jan 4. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 34995792 Free article. Review.
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N. Loo TM, et al. Among authors: arita m. Cancer Discov. 2017 May;7(5):522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15. Cancer Discov. 2017. PMID: 28202625
1,087 results